Publicaciones

Publicaciones IMII 2016

Escaping antiangiogenic therapy: strategies employed by cancer cells. Pinto MP, Sotomayor P, Carrasco-Avino G, Corvalan AH, Owen GI.  International Journal of Molecular Sciences 2016 6;17(9).

Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta. Palacios J, Cifuentes F, Valderrama J, Benites J, Rios D, Gonzalez C, Chiong M, Cartes-Saavedra B, Lafourcade C, Wyneken U, Gonzalez P, Owen GI, Pardo F, Sobrevia L, Buc Calderon P. Oxidative Medicine and Cellular Longevity 2016:3939540.

Evolutionary history of the reprimo tumor suppressor gene family in vertebrates with a description of a new reprimo gene lineage. Wichmann IA, Zavala K, Hoffmann FG, Vandewege MW, Corvalán AH, Amigo JD, Owen GI, Opazo JC. Gene. 2016 Oct 10;591(1):245-54.

Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells. Torres A, Vargas Y, Uribe D, Jaramillo C, Gleisner A, Salazar-Onfray F, López MN, Melo R, Oyarzún C, San Martín R, Quezada C. Oncotarget 2016 7(41):67373-67386.

Dendritic cell chimerism in oral mucosa of transplanted patients affected by graft-versus-host disease. Pérez CA, Rabanales R, Rojas-Alcayaga G, Larrondo M, Escobar AF, López MN, Salazar-Onfray F, Alfaro JI, González FE. J Oral Pathol Med 2016 45(2):127-35.

CitosineAdenineRepeat Microsatellite of 11βhydroxysteroid dehydrogenase 2 Gene in Hypertensive Children. Valdivia C, Carvajal CA, Campino C, Allende F, Martinez‐Aguayo A, Baudrand R, Vecchiola A, Lagos CF, Tapia‐Castillo A, Fuentes CA, Aglony M; Solari S, Kalergis AM, García H, Owen GI, Fardella CE. Am J Hypertens 2016 29(1):25-32.

Aldosterone Production and Signaling Dysregulation in Obesity. Vecchiola A, Lagos CF, Carvajal CA, Baudrand R, Fardella CE. Curr Hypertens 2016 18(3):20.

Role of the ReninAngiotensinAldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension. Muñoz‐Durango N, Fuentes CA, Castillo AE, González‐Gómez LM, Vecchiola A, Fardella CE, Kalergis AM. Int J Mol Sci 2016 17(7). pii: E797.

Cortisol/cortisone ratio and matrix metalloproteinase9 activity are associated with pediatric primary hypertension. Martinez‐Aguayo A, Campino C, Baudrand R, Carvajal CA, García H, Aglony M,Bancalari R, García L, Loureiro C, Vecchiola A, Tapia‐Castillo A, Valdivia C, Sanhueza S, Fuentes CA, Lagos CF, Solari S, Allende F, Kalergis AM, Fardella CE. J Hypertens 2016 34(9):1808-14.

Usefulness and Pitfalls in Sodium Intake Estimation: Comparison of Dietary Assessment and Urinary Excretion in Chilean Children and Adults. Campino C, Hill C, Baudrand R, Martínez‐Aguayo A, Aglony M, Carrasco CA, Ferrada C, Loureiro C, Vecchiola A, Bancalari R, Grob F, Carvajal CA, Lagos CF, Valdivia C, Tapia‐Castillo A, Fuentes CA, Mendoza C, Garcia H, Uauy R, Fardella CE. J Hypertens 2016 29(10):1212-7.

Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents. Carreño LJ, Saavedra-Avila A and Porcelli S. Clinical & Translational Immunology 2016 8;5(4):e69.

Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47. Saini NK, Baena A, Ng TW, Venkatasamy MM, Kennedy SC, Kunnath-Velayudhan S, Carreño LJ, Xu J, Chan J, Larsen MH, Jacobs WR, Jr., and Porcelli SA. Nat Microbiol. 2016 Aug 15;1(9):16133.

The Type of Growth Medium Affects the Presence of a Mycobacterial Capsule and Is Associated With Differences in Protective Efficacy of BCG Vaccination Against Mycobacterium tuberculosis. Prados-Rosales R, Carreño LJ, Weinrick B, Batista-Gonzalez A, Glatman-Freedman A, Xu J, Chan J, Jacobs WR Jr., Porcelli SA and Casadevall A. J Infect Dis. 2016 Aug 1;214(3):426-37.

Modulation of antigen processing by heme-oxygenase 1. Implications on inflammation and tolerance. Riquelme SA, Carreño LJ, Espinoza JA, Mackern-Oberti JP, Alvarez-Lobos MM, Riedel CA, Bueno SM, Kalergis AM. Immunology. 2016 Sep;149(1):1-12.

The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A. Rivas S, Armisén R, Rojas DA, Maldonado E, Huerta H, Tapia JC, Espinoza J, Colombo A, Michea L, Hayman MJ, Marcelain K. J Cell Biochem. 2016;117(2):334-43.

Potential neurocognitive consequences of infection by human Respiratory Syncytial Virus. Flores JC, Bohmwald K, Espinoza J, Jara C, Peña M, Hoyos-Bachiloglu R, Iturriaga C, Kalergis AM, Borzutzky A. Rev Chilena Infectol. 2016 Oct;33(5):537-542.

Parent-Reported Prevalence of Food Allergy in Mexican Schoolchildren: A Population-Based Study, Ontiveros N, Valdez-Meza EE, Vergara-Jiménez MJ, Canizalez-Román A, Borzutzky A, Cabrera-Chávez F. Allergol Immunopathol (Madr). 2016;44(6):563-570.

Humoral and cellular autoreactivity to epidermal proteins in atopic dermatitis. Navarrete-Dechent C, Perez-Mateluna G, Silva-Valenzuela S, Vera-Kellet C, Borzutzky A. Arch Immunol Ther Exp (Warsz). 2016;64(6):435-442

Geographic distribution of Kawasaki disease in Chile. Hoyos-Bachiloglu R, García A, Morales PS, Cerda J, Talesnik E, Borzutzky A.  Rev Chilena Infectol. 2016 Feb;33(1):12-8.

Vitamin D axis and its role in skin carcinogenesis: a comprehensive review. Del Puerto C, Navarrete-Dechent C, Molgo M, Borzutzky A, Gonzalez S. Applied Cancer Research 2016 36:5.

Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection, González AE, Lay MK, Jara EL, Espinoza JA, Gómez RS, Soto J, Rivera CA, Abarca K, Bueno SM, Riedel CA, Kalergis AM. Virulence. 2016 2:1-20.

Opposing roles of IL-10 in acute bacterial infections. Peñaloza HF, Schultz BM, Nieto PA, Salazar GA, Suazo I, Gonzalez PA, Riedel CA, Alvarez-Lobos MM, Kalergis AM, Bueno SM. Cytokine & Growth Factor Rev. 2016 Dec;32:17-30

Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients. Ribeiro CH, Kramm K, Gálvez-Jirón F, Pola V, Bustamante M, Contreras HR, Sabag A, Garrido-Tapia M, Hernández CJ, Zúñiga R, Collazo N, Sotelo PH, Morales C, Mercado L, Catalán D, Aguillón JC, Molina MC. Oncol Rep. 2016 Mar;35(3):1309-17.

Dexamethasone and monophosphoryl lipid A-modulated dendritic cells promote antigen-specific tolerogenic properties on naive and memory CD4+ T cells. Maggi J, Schinnerling K, Pesce B, Hilkens CM, Catalán D, Aguillón JC. Front Immunol. 2016 Sep 19;7:359.

Treatment with dexamethasone and monophosphoryl lipid A removes disease-associated transcriptional signatures in monocyte-derived dendritic cells from rheumatoid Arthritis patients and confers tolerogenic features. García-González PA, Schinnerling K, Sepúlveda-Gutiérrez A, Maggi J, Hoyos L, Morales RA, Mehdi AM, Nel HJ, Soto L, Pesce B, Molina MC, Cuchacovich M, Larrondo ML, Neira Ó, Catalán DF, Hilkens CM, Thomas R, Verdugo RA, Aguillón JC. Front Immunol. 2016 Oct 25;7:458.

Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases. García-González P, Ubilla-Olguín G, Catalán D, Schinnerling K, Aguillón JC (2016) Autoimmun Rev. 2016 15(11):1071-1080.

Infection in Health Personnel with High and Low Levels of Exposure in a Hospital Setting during the H1N1 2009 Influenza A Pandemic. Sandoval C, Barrera SC, A. Ferrés M, Cerda J, Retamal J, Medina R.A, Hirsch T, PLoS One. 2016 11(1): e0147271.

Urinary leukotriene and Bcl I polymorphism of glucocorticoid receptor gene in preschoolers with recurrent wheezing and high risk of asthma. Morales M, Flores C, Pino K, Angulo J, López-Lastra M, Castro-Rodriguez JA. Allergol Immunopathol (Madr). 2016 Jan-Feb;44(1):59-65.

LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex. Angulo J, Ulryck N, Deforges J, Chamond N, Lopez-Lastra M, Masquida B, Sargueil B. Nucleic Acids Res. 2016 Feb 18;44(3):1309-25.

Polypyrimidine tract-binding protein binds to the 5′ untranslated region of the mouse mammary tumor virus mRNA and stimulates cap-independent translation initiation. Cáceres CJ, Contreras N, Angulo J, Vera-Otarola J, Pino-Ajenjo C, Llorian M, Ameur M, Lisboa F, Pino K, Lowy F, Sargueil B, López-Lastra M.  FEBS J. 2016 May;283(10):1880-901.

Structural domains within the HIV-1 mRNA and the ribosomal protein S25 influence cap-independent translation initiation. Carvajal F, Vallejos M, Walters B, Contreras N, Hertz MI, Olivares E, Cáceres CJ, Pino K, Letelier A, Thompson SR, López-Lastra M. FEBS J. 2016 Jul;283(13):2508-27.

Effect of ezetimibe in HCV viral load after liver transplantation. Monrroy-Bravo H, Angulo J, Pino K, Labbé P, López-Lastra M, Soza A. Ann Hepatol. 2016 Sep-Oct;15(5):803-5.

Targeting deoxyhypusine hydroxylase activity impairs cap-independent translation initiation driven by the 5’untranslated region of the HIV-1, HTLV-1, and MMTV mRNAs. Cáceres CJ, Angulo J, Contreras N, Pino K, Vera-Otarola J, López-Lastra M., (2016),Antiviral Res. 2016 Oct;134:192-206.

Avian Influenza Virus H5 Strain with North American and Eurasian Lineage Genes in an Antarctic Penguin. Barriga GP, Boric-Bargetto D, San Martin MC, Neira V, van Bakel H, Thompsom M, Tapia R, Toro-Ascuy D, Moreno L, Vasquez Y, Sallaberry M, Torres-Pérez F, González-Acuña D, Medina RA., (2016). Emerg Infect Dis. 2016 Dec;22(12):2221-2223.

Challenges for Scientists in Latin America. Kalergis AM, Lacerda M, Rabinovich GA, Rosenstein Y. Trends Mol Med. 2016 Sep;22(9):743-5.

Modulation of Host Immunity by the Human Metapneumovirus. Céspedes PF, Palavecino CE, Kalergis AM, Bueno SM. Clin Microbiol Rev. 2016 29(4):795-818.

Innate Immunity and Inflammation in NAFLD/NASH. Arrese M, Cabrera D, Kalergis AM, Feldstein AE. Dig Dis Sci. 2016 May;61(5):1294-303.

Editorial: Searching for immune tolerance manipulating new molecules and exploiting new concepts on lymphocyte biology. Catalán D, Pino-Lagos K. Front Immunol. 2016 Feb 1;7:27. This editorial made an excellent compilation on the current molecules and cell populations that are being aggressively targeted to restore immune tolerance in affected patients.

Acquired resistance to innate immune clearance promotes Klebsiella pneumoniae ST258 pulmonary infection. Ahn D, Peñaloza H, Wang Z, Wickersham M, Parker D, Patel P, Koller A, Chen EI, Bueno SM, Uhlemann AC and Prince A. JCI Insight. 2016 20;1(17):e89704.

Endothelial-to-mesenchymal transition: Cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions. Pérez L, Muñoz-Durango N, Riedel CA, Echeverría C, Kalergis AM, Cabello-Verrugio C, Simon F, Cytokine Growth Factor Rev. 2017 Feb;33:41-54.

Contribution of Fcγ receptors to human respiratory syncytial virus pathogenesis and the impairment of T-cell activation by dendritic cells. Gómez RS, Ramirez BA, Céspedes PF, Cautivo KM, Riquelme SA, Prado CE, González PA, Kalergis AM. Immunology. 2016 Jan;147(1):55-72.

Gestational Hypothyroidism Improves the Ability of the Female Offspring to Clear Streptococcus pneumoniae Infection and to Recover from Pneumococcal Pneumonia. Nieto PA, Peñaloza HF, Salazar-Echegarai FJ, Castellanos RM, Opazo MC, Venegas L, Padilla O, Kalergis AM, Riedel CA, Bueno SM. Endocrinology. 2016 Jun;157(6):2217-28.

Gestational Hypothyroxinemia Affects Glutamatergic Synaptic Protein Distribution and Neuronal Plasticity Through Neuron-Astrocyte Interplay. Cisternas P, Louveau A, Bueno SM, Kalergis AM, Boudin H, Riedel CA. Mol Neurobiol. 2016 Dec;53(10):7158-7169.

Hormonal Modulation of Dendritic Cells Differentiation, Maturation and Function: Implications for the Initiation and Progress of Systemic Autoimmunity. Mackern-Oberti JP, Jara EL, Riedel CA, Kalergis AM., Arch Immunol Ther Exp (2016).

Imprinting of maternal thyroid hormones in the offspring. María Cecilia Opazo, Henny Haensgen, Karen Bohmwald, Luis F. Venegas, Helene Boudin, Alvaro A. Elorza, Felipe Simon, Carlos Fardella, Susan M. Bueno, Alexis M. Kalergis, Claudia A. Riedel. International Reviews of Immunology. (2016).

Human Respiratory Syncytial Virus: Infection and Pathology. Bohmwald K, Espinoza JA, Rey-Jurado E, Gómez RS, González PA, Bueno SM, Riedel CA, Kalergis AM, (2016). Semin Respir Crit Care Med. 2016 Aug;37(4):522-37.

Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling. Kitur K, Wachtel S, Brown A, Wickersham M, Paulino F, Peñaloza HF, Soong G, Bueno S, Parker D, Prince A. Cell Rep. 2016 Aug 23;16(8):2219-30.

Neutrophil/lymphocyte ratio in complete blood count as a mortality predictor in breast cancer. Mimica X, Acevedo F, Oddo D, Ibáñez C, Medina L, Kalergis A, Camus M, Sánchez C. Rev Med Chil. 2016 Jun;144(6):691-6.

New insights about excisable pathogenicity islands in Salmonella and their contribution to virulence. Nieto PA, Pardo-Roa C, Salazar-Echegarai FJ, Tobar HE, Coronado-Arrázola I, Riedel CA, Alexis M. Kalergis AM, Bueno SM. Microbes Infect. 2016 May;18(5):302-9.

 

Publicaciones IMII 2015

Contribution of autophagy to antiviral immunity. Rey-Jurado E, Riedel CA, González PA, Bueno SM, Kalergis AM, (2015), FEBS Lett

Contribution of dendritic cells to the autoimmune pathology of systemic lupus erythematosus, Mackern-Oberti JP, Llanos C, Riedel CA, Bueno SM, Kalergis AM, (2015),Immunology

Elevated IL-3 and IL-12p40 levels in the lower airway of infants with RSV-induced bronchiolitis correlate with recurrent wheezing.  Bertrand P, Lay MK, Piedimonte G, Brockmann PE, Palavecino CE, Hernández J, León MA, Kalergis AM, Bueno SM., (2015),Cytokine, J Cytokine

Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases, Mackern-Oberti JP, Llanos C, Vega F, Salazar-Onfray F, Riedel CA, Bueno SM, Kalergis AM, (2015), Autoimmun Rev

Association of Single-Nucleotide Polymorphisms in IL28B, but Not TNF-α, With Severity of Disease Caused by Andes Virus, Angulo J, Pino K, Echeverría-Chagas N, Marco C, Martínez-Valdebenito C, Galeno H, Villagra E, Vera L, Lagos N, Becerra N, Mora J, Bermúdez A, Cárcamo M, Díaz J, Miquel JF, Ferrés M, López-Lastra M., (2015), Clin Infect Dis. 2015 Dec 15;61(12):e62-9. doi: 10.1093/cid/civ830.

Carbon monoxide impairs mitochondria-dependent endosomal maturation and antigen presentation in dendritic cells. Riquelme SA, Pogu J, Anegon I, Bueno SM, Kalergis AM, (2014), Eur J Immunol. 2015 Oct 2. doi: 10.1002/eji.201545671

Epigenetics and arterial hypertension: the challenge of emerging evidence, Friso S; Carvajal CA; Fardella CE; Olivieri O, (2015), Transl Res. 2015 Jan; 165(1):154-65.

New clinical advances in immunotherapy for the treatment of solid tumours. , Zavala VA, Kalergis AM., (2015), Immunology.

Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus, Mackern-Oberti JP, Obreque J, Méndez GP, Llanos C, Kalergis AM, (2015), Clin Exp Immunol. 2015 Jun 22. doi: 10.1111/cei.12657

Citosine-Adenine-Repeat Microsatellite of 11β-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children. Valdivia C, Carvajal CA, Campino C, Allende F, Martinez-Aguayo A, Baudrand R, Vecchiola A, Lagos CF, Tapia-Castillo A, Fuentes CA, Aglony M, Solari S, Kalergis AM, García H, Owen GI, Fardella CE., (2015), Am J Hypertens.

Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells. Ling L, Camilleri ET, Helledie T, Samsonraj RM, Titmarsh DM, Chua RJ, Dreesen O, Dombrowski C, Rider DA, Galindo M, Lee I, Hong W, Hui JH, Nurcombe V, van Wijnen AJ, Cool SM., (2015), Gene. 576:292-303.

Evasion of early antiviral responses by herpes simplex viruses., Suazo PA, Ibañez FJ, Retamal-Díaz AR, Paz-Fiblas MV, Bueno SM, Kalergis AM, González PA, (2015), Mediators Inflamm. 2015;2015:593757.

Gestational Hypothyroxinemia Affects Glutamatergic Synaptic Protein Distribution and Neuronal Plasticity Through Neuron-Astrocyte Interplay, Cisternas P, Louveau A, Bueno SM, Kalergis AM, Boudin H, Riedel CA., (2015), Mol Neurobiol.

Herpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease. Suazo PA, Tognarelli EI, Kalergis AM, González PA, (2015), Med Microbiol Immunol

Human metapneumovirus infection activates the TSLP pathway that drives excessive pulmonary inflammation and viral replication in mice, Lay MK, Céspedes PF, Palavecino CE, León MA, Díaz RA, Salazar FJ, Méndez GP, Bueno SM, Kalergis AM, (2015), Eur J Immunol. 2015 Jun;45(6):1680-95.

Immune evasion by herpes simplex viruses, Retamal-Díaz AR, Suazo PA, Garrido I, Kalergis AM and González PA, (2015), Rev Chilena Infectol

Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species, Arriagada AA, Albornoz E, Opazo MC, Becerra A, Vidal G, Fardella C, Michea L, Carrasco N, Simon F, Elorza AA, Bueno SM, Kalergis AM, Riedel CA, (2015), Endocrinology

Gene expression profiling of human monocyte-derived dendritic cells – searching for molecular regulators of tolerogenicity, K Schinnerling, P García-González, JC Aguillón, (2015), Frontiers in Immunology

Contribution of Fcγ receptors to human respiratory syncytial virus pathogenesis and the impairment of T-cell activation by dendritic cells, Gómez RS, Ramirez BA, Céspedes PF, Cautivo KM, Riquelme SA, Prado CE, González PA, Kalergis AM., (2015), Immunology

Dendritic cell chimerism in oral mucosa of transplanted patients affected by graft-versus-host disease. Pérez CA, Rabanales R, Rojas-Alcayaga G, Larrondo M, Escobar AF, López MN, Salazar-Onfray F, Alfaro JI, González FE, (2015), Journal of Oral Pathology and Medicine.

Outcome of relapsing Clostridium difficile infections do not correlate with virulence-, spore- and vegetative cell-associated phenotypes, Plaza-Garrido Á, Miranda-Cárdenas C, Castro-Córdova P, Olguín-Araneda V, Cofré-Araneda G, Hernández-Rocha C, Carman R, Ibáñez P, Fawley WN, Wilcox MH, Gil F, Calderón IL, Fuentes JA, Guzmán-Durán AM, Alvarez-Lobos M, Paredes-Sabja D., (2015), Anaerobe

Therapeutic potential of hyporesponsive CD4+ T cells in autoimmunity, J Maggi, C Schäfer, G Ubilla-Olguín, D Catalan, K Schinnerling, JC Aguillón, (2015), Frontiers in Immunology

Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel, Sarmiento D, Montorfano I, Cerda O, Cáceres M, Becerra A, Cabello-Verrugio C, Elorza AA, Riedel C, Tapia P, Velásquez LA, Varela D, Simon F, (2015),Microvasc Res.

Inflammatory damage on respiratory and nervous systems due to hRSV infection, Bohmwald K, Espinoza JA, Becerra D, Rivera K, Lay MK, Bueno SM, Riedel CA, Kalergis AM, (2015),Curr Opin Immunol.

Interleukin-10 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by Streptococcus pneumoniae. Peñaloza HF, Nieto PA, Muñoz-Durango N, Salazar-Echegarai FJ, Torres J, Parga MJ, Alvarez-Lobos M, Riedel CA, Kalergis AM, Bueno SM., (2015),  Immunology

Intravenous administration of bone marrow-derived mesenchymal stem cells induces a switch from classical to atypical symptoms in experimental autoimmune encephalomyelitis, Kurte M, Bravo-Alegría J, Torres A, Carrasco V, Ibáñez C, Vega-Letter AM, Fernández-O’Ryan C, Irarrázabal CE, Figueroa FE, Fuentealba RA, Riedel C, Carrión F, (2015), Stem Cells Int.

Metabolic syndrome and its components are strongly associated with an inflammatory state and insulin resistance in the pediatric population, Loureiro C, Godoy A, Martínez A, Campino C, Aglony M, Bancalari R, Mendoza C, Cerda J, Carvajal C, Arnaiz P, Fardella C, García H, (2015), Nutr Hosp. 2015 Apr 1; 31(4):1513-8

Neuropilin-1+ regulatory T cells promote skin allograft survival and modulate effector CD4+ T cells phenotypic signature, M Campos-Mora, R Morales, F Pérez, T Gajardo, J Campos-Acuña, D Catalan, JC Aguillón, K Pino-Lagos, (2015), Immunology and Cell Biology

LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex., Angulo J, Ulryck N, Deforges J, Chamond N, Lopez-Lastra M, Masquida B, Sargueil B., (2015), Nucleic Acids Res.

Role of Dendritic Cells in the Induction of Lymphocyte Tolerance, Fabiola Osorio, Camila Fuentes, Mercedes N López, Flavio Salazar-Onfray, Fermín E González, (2015), Frontiers in Immunology

Skewing dendritic cell differentation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis, K Schinnerling, L Soto, P García-González, D Catalán, JC Aguillón, (2015), Autoimmunity Reviews

Systemic Sclerosis Patients Present Alterations in the Expression of Molecules Involved in B-Cell Regulation, L Soto, A Ferrier, O Aravena, E Fonseca, J Berendsen, A Biere, D Bueno, V Ramos, JC Aguillón, D Catalán, (2015), Frontiers in Immunology

Tumor cells lysates as inmunogenic sources for cancer vaccine desing, Fermín E. González, Alejandra Gleisner, Felipe Falcón-Beas, Fabiola Osorio, Mercedes N López y Flavio Salazar-Onfray, (2015), Human vaccines and Immunotherapeutics, 10(11), 3261-3269.

The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A., Rivas S, Armisén R, Rojas DA, Maldonado E, Huerta H, Tapia JC, Espinoza J, Colombo A, Michea L, Hayman MJ, Marcelain K., (2016), J Cell Biochem

Mitotic inheritance of mRNA facilitates translational activation of the osteogenic-lineage commitment factor Runx2 in progeny of osteoblastic cells., Nelson Varela, Alejandra Aranguiz, Carlos Lizama, Hugo Sepulveda, Marcelo Antonelli, Roman Thaler, Ricardo D. Moreno, Martin Montecino, Gary S. Stein, Andre J. van Wijnen, and Mario Galindo (2015), J Cell Phys

Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone, Muñoz-Durango N, Vecchiola A, Gonzalez-Gomez LM, Simon F, Riedel CA, Fardella CE, Kalergis AM. (2015), Biomed Res Int. 2015;2015:652738. doi: 10.1155/2015/652738.

New insights on the viral and host factors contributing to the airway pathogenesis caused by the respiratory syncytial virus. Lay MK, Bueno SM, Gálvez N, Riedel CA, Kalergis AM, (2015), Crit Rev Microbiol. 2015 Jun 29:1-13.

Novel therapies and vaccines against the human respiratory syncytial virus. Rivera CA, Gómez RS, Díaz RA, Céspedes PF, Espinoza JA, González PA, Riedel CA, Bueno SM, Kalergis AM., (2015), Expert Opin Investig Drugs. 2015 Oct 12:1-18.

Overexpression of connexin 43 reduces melanoma proliferative and metastatic capacity, Tittarelli A, Guerrero I, Tempio F, Gleisner MA, Avalos I, Sabanegh S, Ortiz C, Michea L, López MN, Mendoza-Naranjo A, Salazar-Onfray F., (2015), British Journal of Cancer; 113(2), 259-67.

Pregnancy normalized familial hyperaldosteronism type I: a novel role for progesterone? Campino C, Trejo P, Carvajal CA, Vecchiola A, Valdivia C, Fuentes CA, Delgado JF, Lagos CF, Aglony M, Carrasco C, Martinez-Aguayo A, García H, Loureiro C, Fardela CE, (2015), Hum Hypertens. 2015 Feb;29(2):138-9

Purification and characterization of saxitoxin from Mytilus chilensis of southern Chile. Rubio DP, Roa LG, Soto DA, Velasquez FJ, Gregorcic NA, Soto JA, Martinez MC, Kalergis AM, Vasquez AE., (2015), Toxicon. 2015 Oct 1. pii: S0041-0101(15)30102-1. doi: 10.1016/j.toxicon.2015.09.045

Understanding Lung Immunopathology Caused by the Human Metapneumovirus: Implications for Rational Vaccine Design, Palavecino CE, Cespedes PF, Lay MK, Riedel CA, Kalergis AM, Bueno SM., (2015), Critical Reviews in Immunology

Urinary leukotriene and Bcl I polymorphism of glucocorticoid receptor gene in preschoolers with recurrent wheezing and high risk of asthma., Morales M, Flores C, Pino K, Angulo J, López-Lastra M, Castro-Rodriguez JA, (2015), Allergol Immunopathol (Madr).

Vascular mineralocorticoid receptor and blood pressure regulation., Tarjus A, Amador C, Michea L, Jaisser F., (2015), Curr Opin Pharmacol.

Vitamin D levels and vitamin D receptor gene polymorphisms in asthmatic children: a case-control study., Einisman H, Reyes ML, Angulo J, Cerda J, López-Lastra M, Castro-Rodriguez JA, (2015), Pediatr Allergy Immunol.

Transactivation activity and nucleocytoplasmic transport ofβ-catenin are independently regulated by its C-terminal end, Maturana J.L., Niechi I., Silva-Pavez E., Huerta-Castro H., Cataldo R., Härtel S., Barros L.F., Galindo M., Tapia J.C., Gene (2015).

Rapamycin-conditioned dendritic cells activated with monophosphoryl lipid-A promote allograft acceptance in vivo, J Campos-Acuña, F Pérez, E Narváez, M Campos-Mora, T Gajardo, D Catalán, JC Aguillón, K Pino-Lagos, (2015), Immunotherapy

Retinaldehyde dehydrogenase activity is triggered during allograft rejection and it drives Th1/Th17 cytokine production, R Morales, M Campos-Mora, T Gajardo, F. Pérez, J Campos, JC Aguillón, K Pino-Lagos, (2015), Immunobiology

Structure-based pharmacophore identification of selective 11beta-HSD1 inhibitors, Lagos, C. F.; Ortiz-Canales, D.; Fuentes-Ibacache, N.; Allende, F.; Fuentes, C. A.; Gonzalez-Gomez, L. M.; Campino, C.; Baudrand, R.; Carvajal, C. A.; Solari, S.; Cifuentes, M.; Vecchiola, A.; Fardella, C., (2015), Chemical Biology & Drug Design

Toxin-induced necroptosis is a major mechanism of Staphylococcus aureus lung damage. Kitur K, Parker D, Nieto P, Ahn DS, Cohen TS, Chung S, Wachtel S, Bueno S, Prince A. PLoS Pathogen DOI:10.1371/journal.ppat.1004820 April 16, 2015.

The Expression of RAC1 and Mineralocorticoid Pathway-Dependent Genes are Associated With Different Responses to Salt Intake. Tapia-Castillo A, Carvajal CA, Campino C, Hill C, Allende F, Vecchiola A, Carrasco C, Bancalari R, Valdivia C, Lagos C, Martinez-Aguayo A, Garcia H, Aglony M, Baudrand RF, Kalergis AM, Michea LF, Riedel CA, Fardella CE. Am J Hypertens. 2015 Jun;28(6):722-8. doi: 10.1093/ajh/hpu224

Publicaciones IMII 2014

Central nervous system alterations caused by infection with the human respiratory syncytial virus.
Bohmwald K, Espinoza JA, González PA, Bueno SM, Riedel CA, Kalergis AM.
Rev Med Virol. 2014 Nov;24(6):407-19. doi: 10.1002/rmv.1813. Epub 2014 Oct 14.

Conjugal transfer of the pathogenicity island ROD21 in Salmonella enterica serovar Enteritidis depends on environmental conditions.
Salazar-Echegarai FJ, Tobar HE, Nieto PA, Riedel CA, Bueno SM.
PLoS One. 2014 Apr 4;9(4):e90626. doi: 10.1371/journal.pone.0090626.

Modulation of host adaptive immunity by hRSV proteins.
Espinoza JA, Bohmwald K, Céspedes PF, Riedel CA, Bueno SM, Kalergis AM.
Virulence. 2014 Aug 5;5(7). [Epub ahead of print] Review.

The 5′ untranslated region of the human T-cell lymphotropic virus type 1 mRNA enables cap-independent translation initiation.
Olivares E, Landry DM, Cáceres CJ, Pino K, Rossi F, Navarrete C, Huidobro-Toro JP, Thompson SR, López-Lastra M.
J Virol. 2014 Jun;88(11):5936-55. doi: 10.1128/JVI.00279-14. Epub 2014 Mar 12.

Respiratory Syncytial Virus: Pathology, therapeutic drugs and prophylaxis.
Gomez RS, Guisle-Marsollier I, Bohmwald K, Bueno SM, Kalergis AM.
Immunol Lett. 2014 Sep 28. pii: S0165-2478(14)00194-1. doi:

Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system.
Ocaranza MP, Michea L, Chiong M, Lagos CF, Lavandero S, Jalil JE.
Clin Sci (Lond). 2014 Nov;127(9):549-57. doi: 10.1042/CS20130449. Review.

Reply: dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure.
Ocaranza MP, Michea L, Chiong M, Lavandero S, Jalil JE.
J Hypertens. 2014 Aug;32(8):1719-21. doi: 10.1097/HJH.0000000000000247. No

Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis.
Ocaranza MP, Moya J, Barrientos V, Alzamora R, Hevia D, Morales C, Pinto M, Escudero N, García L, Novoa U, Ayala P, Díaz-Araya G, Godoy I, Chiong M, Lavandero S, Jalil JE, Michea L.
J Hypertens. 2014 Apr;32(4):771-83. doi: 10.1097/HJH.0000000000000094.

Targeting dendritic cell function during systemic autoimmunity to restore tolerance.
Mackern-Oberti JP, Vega F, Llanos C, Bueno SM, Kalergis AM.
Int J Mol Sci. 2014 Sep 16;15(9):16381-417. doi: 10.3390/ijms150916381. Review.

Herpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease.
Suazo PA, Tognarelli EI, Kalergis AM, González PA.
Med Microbiol Immunol. 2014 Sep 11. [Epub ahead of print]

Carbon monoxide down-modulates TLR4/MD2 expression on innate immune cells and reduces endotoxic shock susceptibility.
Riquelme SA, Bueno SM, Kalergis AM.
Immunology. 2014 Sep 1. doi: 10.1111/imm.12375. [Epub ahead of print]

Dietary effect on immunological energetics in mice.
Martel SI, Riquelme SA, Kalergis AM, Bozinovic F.
J Comp Physiol B. 2014 Oct;184(7):937-44. doi: 10.1007/s00360-014-0852-x. Epub 2014 Aug 17.

Surface expression of the hRSV nucleoprotein impairs immunological synapse formation with T cells.
Céspedes PF, Bueno SM, Ramírez BA, Gomez RS, Riquelme SA, Palavecino CE, Mackern-Oberti JP, Mora JE, Depoil D, Sacristán C, Cammer M, Creneguy A, Nguyen TH, Riedel CA, Dustin ML, Kalergis AM.
Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3214-23. doi: 10.1073/pnas.1400760111. Epub 2014 Jul 23.

A novel live vector group A streptococcal emm type 9 vaccine delivered intranasally protects mice against challenge infection with emm type 9 group A streptococci.
Wozniak A, García P, Geoffroy EA, Aguirre DB, González SA, Sarno VA, Dale JB, Salazar-Echegarai FJ, Vera A, Bueno SM, Kalergis AM.
Clin Vaccine Immunol. 2014 Sep;21(9):1343-9. doi: 10.1128/CVI.00330-14. Epub 2014 Jul 23.

Induction of protective effector immunity to prevent pathogenesis caused by the respiratory syncytial virus. Implications on therapy and vaccine design.
Espinoza JA, Bueno SM, Riedel CA, Kalergis AM.
Immunology. 2014 Sep;143(1):1-12. doi: 10.1111/imm.12313. Review.

Heme oxygenase-1 as a target for the design of gene and pharmaceutical therapies for autoimmune diseases.
Mackern-Oberti JP, Riquelme SA, Llanos C, Schmidt CB, Simon T, Anegon I, Jara E, Riedel CA, Bueno SM, Kalergis AM.
Curr Gene Ther. 2014;14(3):218-35.

Independent anti-angiogenic capacities of coagulation factors X and Xa.
Lange S, Gonzalez I, Pinto MP, Arce M, Valenzuela R, Aranda E, Elliot M, Alvarez M, Henriquez S, Velasquez EV, Orge F, Oliva B, Gonzalez P, Villalon M, Cautivo KM, Kalergis AM, Pereira K, Mendoza C, Saez C, Kato S, Cuello MA, Parborell F, Irusta G, Palma V, Allende ML, Owen GI.
J Cell Physiol. 2014 Nov;229(11):1673-80. doi: 10.1002/jcp.24612.

Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes.
Amador CA, Barrientos V, Peña J, Herrada AA, González M, Valdés S, Carrasco L, Alzamora R, Figueroa F, Kalergis AM, Michea L.
Hypertension. 2014 Apr;63(4):797-803.

Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity.
Tittarelli A, Mendoza-Naranjo A, Farías M, Guerrero I, Ihara F, Wennerberg E, Riquelme S, Gleisner A, Kalergis A, Lundqvist A, López MN, Chambers BJ, Salazar-Onfray F.
J Immunol. 2014 Feb 1;192(3):1313-9. doi: 10.4049/jimmunol.1301297. Epub 2013 Dec 27.

Immunization with a recombinant bacillus Calmette-Guerin strain confers protective Th1 immunity against the human metapneumovirus.
Palavecino CE, Céspedes PF, Gómez RS, Kalergis AM, Bueno SM.
J Immunol. 2014 Jan 1;192(1):214-23. doi: 10.4049/jimmunol.1300118. Epub 2013 Dec 6.

Respiratory syncytial virus detection in cells and clinical samples by using three new monoclonal antibodies.
Gómez RS, Mora JE, Cortés CM, Riedel CA, Ferrés M, Bueno SM, Kalergis AM.
J Med Virol. 2014 Jul;86(7):1256-66. doi: 10.1002/jmv.23807. Epub 2013 Oct 22.

Herpes simplex virus type 2 glycoprotein H interacts with integrin αvβ3 to facilitate viral entry and calcium signaling in human genital tract epithelial cells.
Cheshenko N, Trepanier JB, González PA, Eugenin EA, Jacobs WR Jr, Herold BC.
J Virol. 2014 Sep 1;88(17):10026-38. doi: 10.1128/JVI.00725-14. Epub 2014 Jun 18.

Endotoxin-induced endothelial fibrosis is dependent on expression of transforming growth factors β1 and β2.
Echeverría C, Montorfano I, Tapia P, Riedel C, Cabello-Verrugio C, Simon F.
Infect Immun. 2014 Sep;82(9):3678-86. doi: 10.1128/IAI.02158-14. Epub 2014 Jun 16.

Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel.
Sarmiento D, Montorfano I, Cerda O, Cáceres M, Becerra A, Cabello-Verrugio C, Elorza AA, Riedel C, Tapia P, Velásquez LA, Varela D, Simon F.
Microvasc Res. 2014 Feb 9. pii: S0026-2862(14)00032-6. doi: 10.1016/j.mvr.2014.02.001. [Epub ahead of print]

Adaptive responses of mitochondria to mild copper deprivation involve changes in morphology, OXPHOS remodeling and bioenergetics.
Ruiz LM, Jensen EL, Bustos RI, Argüelloa G, Gutierrez-Garcia R, González M, Hernández C, Paredes R, Simon F, Riedel C, Ferrick D, Elorza AA.
J Cell Physiol. 2014 May;229(5):607-19. doi: 10.1002/jcp.24484.

Epigenetics and arterial hypertension: the challenge of emerging evidence.
Friso S, Carvajal CA, Fardella CE, Olivieri O.
Transl Res. 2014 Jun 25. pii: S1931-5244(14)00214-X. doi: 10.1016/j.trsl.2014.06.007. [Epub ahead of print] Review.

Pregnancy normalized familial hyperaldosteronism type I: a novel role for progesterone?
Campino C, Trejo P, Carvajal CA, Vecchiola A, Valdivia C, Fuentes CA, Delgado JF, Lagos CF, Aglony M, Carrasco C, Martinez-Aguayo A, García H, Loureiro C, Fardella CE.
J Hum Hypertens. 2014 Jun 19. doi: 10.1038/jhh.2014.49. [Epub ahead of print] No abstract available.

LC-MS/MS Method for the Simultaneous Determination of Free Urinary Steroids.
Allende F, Solari S, Campino C, Carvajal CA, Lagos CF, Vecchiola A, Valdivia C, Baudrand R, Owen GI, Fardella CE.
Chromatographia. 2014;77:637-642. Epub 2014 Feb 11.

Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a Chilean pediatric population.
Tapia-Castillo A, Carvajal CA, Campino C, Vecchiola A, Allende F, Solari S, García L, Lavanderos S, Valdivia C, Fuentes C, Lagos CF, Martínez-Aguayo A, Baudrand R, Aglony M, García H, Fardella CE.
Am J Hypertens. 2014 Mar;27(3):299-307. doi: 10.1093/ajh/hpt277. Epub 2014

Identification of novel 11β-HSD1 inhibitors by combined ligand- and structure-based virtual screening.
Lagos CF, Vecchiola A, Allende F, Fuentes CA, Tichauer JE, Valdivia C, Solari S, Campino C, Tapia-Castillo A, Baudrand R, Villarroel P, Cifuentes M, Owen GI, Carvajal CA, Fardella CE.
Mol Cell Endocrinol. 2014 Mar 25;384(1-2):71-82. doi: 10.1016/j.mce.2014.01.011.

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro.
Vecchiola A, Lagos CF, Fuentes CA, Allende F, Campino C, Valdivia C, Tapia-Castillo A, Ogishima T, Mukai K, Owen G, Solari S, Carvajal CA, Fardella CE.
Reprod Biol Endocrinol. 2013 Aug 13;11:76. doi: 10.1186/1477-7827-11-76.

High sodium intake is associated with increased glucocorticoid production, insulin resistance and metabolic syndrome.
Baudrand R, Campino C, Carvajal CA, Olivieri O, Guidi G, Faccini G, Vöhringer PA, Cerda J, Owen G, Kalergis AM, Fardella CE.
Clin Endocrinol (Oxf). 2014 May;80(5):677-84. doi: 10.1111/cen.12225. Epub 2013 May 15.

Neuropilin-1+ regulatory T cells promote skin allograft survival and modulate effector CD4+ T cells phenotypic signature.
Campos-Mora M, Morales RA, Pérez F, Gajardo T, Campos J, Catalan D, Aguillón JC, Pino-Lagos K.
Immunol Cell Biol. 2014 Sep 23. doi: 10.1038/icb.2014.77. [Epub ahead of print]

Publicaciones IMII 2013

Role of Salmonella enterica exposure in chilean Crohn’s disease patients.
Alvarez-Lobos M, Pizarro DP, Palavecino CE, Espinoza A, Sebastian VP, Alvarado JC, Ibañez P, Quintana C, Díaz O, Kalergis AM, Bueno SM.
World Journal of Gastroenterology. 2013, 19(35):5855-62.

Impaired learning resulting from respiratory syncytial virus infection.
Espinoza JA, Bohmwald K, Céspedes PF, Gómez RS, Riquelme SA, Cortés CM, Valenzuela JA, Sandoval RA, Pancetti FC, Bueno SM, Riedel CA, Kalergis AM
Proc Natl Acad Sci, 2013, 110(22):9112-7

Gene elements that regulate Streptococcus pneumoniae virulence and immunity evasion.

Nieto PA, Riquelme SA, Riedel CA, Kalergis AM, Bueno SM.
Current Gene Therapy. 2013. 13(1): 51-64.

Human Metapneumovirus keep dendritic cells from priming antigen-specific naive T cells.
Cespedes, PF, Gonzalez PA, Kalergis AM.
Immunology, 2013, 139 (9):366-76

Carbon monoxide exposure improves immune function in lupus-prone mice.
Mackern-Oberti JP, Llanos C, Carreño LJ, Riquelme SA, Jacobelli SH, Anegon I, Kalergis AM.
Immunology. 2013 Sep;140(1):123-32

WebRASP: a server for computing energy scores to assess the accuracy and stability of RNA 3D structures.
Norambuena, T., Cares, J.F., Capriotti, E., Melo, F.
Bioinformatics. 2013 Oct 15; 29(20):2649-50.

Towards the development of standardized methods for comparison, ranking and evaluation of structure alignments.
Slater, A.W., Castellanos, J.I., Sippl, M.J., Melo, F.
Bioinformatics. 2013 Jan 1; 29(1):47-53.

A cis-acting element present within the gag coding region negatively impacts on IRES-mediated translation from the full length HIV-1 mRNA.
F. Valiente-Echeverría, M. Vallejos, A. Monette, A. Letelier, K. Pino, F. E. Rodriguez, C. Navarrete, J. P. Huidobro-Toro, A. J. Mouland, M.López-Lastra.
PLoS One. 2013;8(2):e56962

Dual mechanisms of translation initiation of the full-length HIV-1 mRNA contribute to Gag synthesis.
A. Monette, F. Valiente-Echeverría, M. Rivero, É. A Cohen, M. Lopez-Lastra, A.J. Mouland.
PLoS One. 2013; 8(7):e68108

Genetic variations in host IL28B links to the detection of peripheral blood mononuclear cells associated hepatitis C virus RNA in chronically infected patients.
Angulo J, Pino K, Pavez C, Biel F, Labbé P, Miquel JF, Soza A, M. López-Lastra.
J Viral Hepat. 2013;20(4):263-272

Translation initiation is driven by different mechanisms on the HIV-1 and HIV-2 genomic RNAs.
S. de Breyne, R. Soto-Rifo, M. López-Lastra, T. Ohlmann.
Virus Research 2013;171(2):366-81

IL28B Polymorphisms Among Latin American HCV Patients.
A. Soza and M. López-Lastra.
Curr Hepatitis Rep (2013) 12:276–279

Steroid withdrawal in pediatric kidney transplant allows better growth, lipids and body composition: a randomized controlled trial.
Mericq V, Salas P, Pinto V, Cano F, Reyes L, Brown K, Gonzalez M, Michea L, Delgado I, Delucchi A.
Horm Res Paediatr 2013, 79(2):88-96

Influence of glucose metabolism on vascular smooth muscle cell proliferation.
Chiong M, Morales P, Torres G, Gutiérrez T, García L, Ibacache M, Michea L.
Vasa 2013, 42(1):8-16.

MicroRNA-34c Inversely Couples the Biological Functions of the Runt-related Transcription Factor RUNX2 and the Tumor Suppressor p53 in Osteosarcoma.
van der Deen, M. (1st author), Taipaleenmäki, H., Zhang, Y., Teplyuk, N.M., Gupta, A., Cinghu, S., Shogren, K., Maran, A., Yaszemski, M.J., Ling, L., Cool, S.M., Leong, D.T., Dierkes, C., Zustin, J., Salto-Tellez, M., Ito, Y., Bae, S.C., Zielenska, M., Squire, J.A., Lian, J.B., Stein, J.L., Zambetti, G.P., Jones, S.N., Galindo, M. [PI], Hesse, E., Stein, G.S., van Wijnen, A.J.
J Biol Chem. 2013, 288(29):21307-21319.

The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines.
Lucero, C.M., Vega, O.A., Osorio, M.M., Tapia, J.C., Antonelli, M., Stein, G.S., van Wijnen, A.J., Galindo, M.A..
J Cell Physiol. 2013. 228(4):714-723.

Dexamethasone preconditioning improves the response of collagen-induced arthritis to treatment with short-term lipopolysaccharide-stimulated collagen-loaded dendritic cells.
Peña C, Gárate D, Contreras-Levicoy J, Aravena O, Catalán D, Aguillón JC.
Clin Dev Immunol. 2013;2013:296031

A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines.
García-González P, Morales R, Hoyos L, Maggi J, Campos J, Pesce B, Gárate D, Larrondo M, González R, Soto L, Ramos V, Tobar P, Molina MC, Pino-Lagos K, Catalán D, Aguillón JC.
J Transl Med. 2013; 11: 128.

Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients.
Pesce B, Soto L, Sabugo F, Wurmann P, Cuchacovich M, López MN, Sotelo PH, Molina MC, Aguillón JC, Catalán D.
Clin Exp Immunol. 2013 Mar;171(3):237-42.

Blocking of p38 and transforming growth factor β receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis.
Gárate D, Rojas-Colonelli N, Peña C, Salazar L, Abello P, Pesce B, Aravena O, García-González P, Ribeiro CH, Molina MC, Catalán D, Aguillón JC.
Arthritis Rheum. 2013 Jan;65(1):120-9.

Positive association between aldosterone-renin ratio and carotid intima-media thickness in hypertensive children.
Loureiro, C.; Campino, C.; Martinez-Aguayo, A.; Godoy, I.; Aglony, M.; Bancalari, R.; Garcia, H.; Carvajal, C.A.; Fardella, C.
Clinical endocrinology. 2013, 38 (3) 352-357.

Age-related changes in 11β-hydroxysteroid dehydrogenase type 2 activity in normotensive subjects.
Campino, C.; Martinez-Aguayo, A.; Baudrand, R.; Carvajal, C.A.; Aglony, M.; Garcia, H.; Padilla, O.; Kalergis, A.M.; Fardella, C.E.
American journal of hypertension. 2013, 26 (4) 481-487.

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro.
Vecchiola, A.; Lagos, C.F.; Fuentes, C.A.; Allende, F.; Campino, C.; Valdivia, C.; Tapia-Castillo, A.; Ogishima, T.; Mukai, K.; Owen, G.; Solari, S.; Carvajal, C.A.; Fardella, C.E.
Reproductive biology and endocrinology, 2013, RB&E. 11 (1) 76.

Immune system alterations by aldosterone during hypertension: from clinical observations to genomic and non-genomic mechanisms leading to vascular damage.
Muñoz-Durango, N.; Barake, M.F.; Letelier, N.A.; Campino, C.; Fardella, C.E.; Kalergis, A.M.
Current molecular medicine. 2013, 13 (6) 1035-1046

Gestational Hypothyroidism Increases the Severity of Experimental Autoimmune Encephalomyelitis in Adult Offspring.
Eduardo A. Albornoz, Leandro J. Carreño, Claudia M. Cortes, Pablo A. Gonzalez, Pablo A. Cisternas, Kelly M. Cautivo, Tamara P. Catalán, M. Cecilia Opazo, Eliseo A. Eugenin, Joan W. Berman, Susan M. Bueno, Alexis M. Kalergis, and Claudia A. Riedel.
Thyroid. 2013 Dec;23(12):1627-37

Impaired Spatial Memory in Mice Lacking CD3ζ Is Associated with Altered NMDA and AMPA Receptors Signaling Independent of T-Cell Deficiency.
A Louveau, J Angibaud, F Haspot, MC Opazo, R Thinard, V Thepenier, SJ Baudouin SJ, Lescaudron L, Hulin P, Riedel CA, Boudin H.(
J Neurosciencie. Nov 20;33(47):18672-85. 2013.

Respiratory syncytial virus detection in cells and clinical samples by using three new monoclonal antibodies.
Gómez RS, Mora JE, Cortés CM, Riedel CA, Ferrés M, Bueno SM, Kalergis AM. (2013)
J Med Virol. 2013 Oct 22. doi: 10.1002/jmv.23807. PMID: 24150877.

Copper deficiency alters cell bioenergetics and induces mitochondrial fusion through up-regulation of MFN2 and OPA1 in erythropoietic cells.
Bustos RI, Jensen EL, Ruiz LM, Rivera S, Ruiz S, Simon F, Riedel C, Ferrick D, Elorza AA.
Biochem Biophys Res Commun. 2013 Aug 2;437(3):426-32.

Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells.
Echeverría C, Montorfano I, Sarmiento D, Becerra A, Nuñez-Villena F, Figueroa XF, Cabello-Verrugio C, Elorza AA, Riedel C, Simon F.
J Cell Mol Med. 2013 Jun;17(6):800-14.

Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells.
Tardif V, Riquelme SA, Remy S, Carreño LJ, Cortés CM, Simon T, Hill M, Louvet C, Riedel CA, Blancou P, Bach JM, Chauveau C, Bueno SM, Anegon I, Kalergis AM.
Eur J Immunol. 2013 Jul 15. doi: 10.1002/eji.201343600.

Modulation of tumor immunity by soluble and membrane-bound molecules at the immunological synapse.
González PA, Carreño LJ, Céspedes PF, Bueno SM, Riedel CA, Kalergis AM.
Clin Dev Immunol 2013;2013:450291. doi: 10.1155/2013/450291.Epub 2013 Mar 7.

Advances in understanding respiratory syncytial virus infection in airway epithelial cells and consequential effects on the immune response.
Lay MK, González PA, León MA, Céspedes PF, Bueno SM, Riedel CA, Kalergis AM.
Microbes Infect. 2013 Mar;15(3):230-242.

Nutritional status modulates plasma leptin, AMPK and TOR activation, and mitochondrial biogenesis: implications for cell metabolism and growth in skeletal muscle of the fine flounder.
Fuentes, EN, Safian, D, Einarsdottir, IE, Valdés, JA, Elorza, AA, Molina, A, Bjornsson, BT.
General and Comparative Endocrinology, 2013 186 (6): 172-180

Adaptive responses of mitochondria in mice under mild copper deprivation involve changes in morphology, oxphos remodeling, and bioenergetics.
Ruiz LM, Jensen EL, Bustos RI, Arguello AG, Gutierrez-Garcia R, Gonzalez M, Hernandez C, Paredes R, Simon F, Riedel C, Ferrick D, Elorza AA.
Jounal of Celular Physiology, 2013. DOI: 10.1002/jcp.24484

Neisseria gonorrhoeae induces a tolerogenic phenotype in macrophages to modulate host immunity.
Escobar A, Candia E, Reyes-Cerpa S, Villegas-Valdes B, Neira T, Lopez MN, Maisey K, Tempio F, Ríos M, Acuña-Castillo C, Imarai M.
Mediators Inflamm. 2013;2013:127017. doi: 10.1155/2013/127017. Epub 2013 Sep 24.

Melanocortin 1 Receptor-derived peptides are efficiently recognized by cytotoxic T lymphocytes from melanoma patients.
González FE, Ramírez M, Allerbring EB, Fasching N, Lundqvist A, Poschke I, Achour A, Salazar-Onfray F.
Immunobiology, 2013 2985(13).

Tumour cell lysate-loaded dendritic cell vaccine induces biochemical and memory immune response in castration-resistant prostate cancer patients.
Reyes D, Salazar L, Espinoza E, Pereda C, Castellón E, Valdevenito R, Huidobro C, Inés Becker M, Lladser A, López MN, Salazar-Onfray F.
British Journal of Cancer, 2013, 109(6):1488-1497.

The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated with increased Th1/Th17 and reduced Th3 cytokine responses.
Durán-Aniotz C, Segal G, Salazar L, Pereda C, Falcón C, Tempio F, Aguilera R, González R, Pérez C, Tittarelli A, Catalán D, Nervi B, Larrondo M, Salazar-Onfray F, López MN.
Cancer Inmunology, Immunotherapy, 2013, 62(4):761-772

Chromosomal excision of a new pathogenicity island modulates Salmonella virulence in vivo.
Tobar HE, Salazar-Echegarai FJ, Nieto PA, Palavecino CE, Sebastian VP, Riedel CA, Kalergis AM, Bueno SM.
Current Gene Therapy, 2013 13(4): 240-9

Tolerogenic dendritic cells as a therapy for treating lupus.
Llanos C, Mackern-Oberti JP, Vega F, Jacobelli SH, Kalergis AM.
Clin Immunol. 2013 Aug;148(2):237-45.

Understanding respiratory syncytial virus infection to improve treatment and immunity.
Pablo A. González, Leandro J. Carreño, Susan M. Bueno, Claudia A. Riedel and Alexis M. Kalergis.
Curr Mol Med. 2013 Aug;13(7):1122-39.

High sodium intake is associated with increased glucocorticoid production, insulin resistance and metabolic syndrome.
Baudrand R, Campino C, Carvajal CA, Olivieri O, Guidi G, Faccini G, Vöhringer PA, Cerda J, Owen G, Kalergis AM, Fardella CE
Clin Endocrinol (Oxf). 2013 Apr 17. doi: 10.1111/cen.12225.

 

Interplay between behavioural thermoregulation and immune response in mealworms.
Catalán TP, Niemeyer HM, Kalergis AM, Bozinovic F.
J Insect Physiol. 2012 Sep 14. pii: S0022-1910(12)00212-0. doi: 10.1016/j.jinsphys.2012.08.011. [Epub ahead of print]
PMID: 22985859

The blocking of p38 and transforming growth factor-β receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis.
Gárate D, Rojas-Colonelli N, Peña C, Salazar L, Abello P, Pesce B, Aravena O, García-González P, Ribeiro CH, Molina MC, Catalán D, Aguillón JC.
Arthritis Rheum. 2012 Sep 12. doi: 10.1002/art.37702. [Epub ahead of print]
PMID: 22972370

The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines.
Lucero C, Vega O, Osorio M, Tapia JC, Antonelli M, Stein GS, van Wijnen AJ, Galindo M.
J Cell Physiol. 2012 Sep 4. doi: 10.1002/jcp.24218. [Epub ahead of print]
PMID: 22949168

Hypothyroidism in the adult rat causes incremental changes in brain-derived neurotrophic factor, neuronal and astrocyte apoptosis, gliosis, and deterioration of postsynaptic density.
Cortés C, Eugenin E, Aliaga E, Carreño LJ, Bueno SM, Gonzalez PA, Gayol S, Naranjo D, Noches V, Marassi MP, Rosenthal D, Jadue C, Ibarra P, Keitel C, Wohllk N, Court F, Kalergis AM, Riedel CA.
Thyroid. 2012 Sep;22(9):951-63. Epub 2012 Aug 7.
PMID: 22870949

Mechanisms used by virulent Salmonella to impair dendritic cell function and evade adaptive immunity.
Bueno SM, Riquelme S, Riedel CA, Kalergis AM.
Immunology. 2012 Sep;137(1):28-36. doi: 10.1111/j.1365-2567.2012.03614.x.
PMID: 22703384

Haem oxygenase 1 expression is altered in monocytes from patients with systemic lupus erythematosus.
Herrada AA, Llanos C, Mackern-Oberti JP, Carreño LJ, Henriquez C, Gómez RS, Gutierrez MA, Anegon I, Jacobelli SH, Kalergis AM.
Immunology. 2012 Aug;136(4):414-24. doi: 10.1111/j.1365-2567.2012.03598.x.
PMID: 22587389

Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia.
Pérez-Sepúlveda A, Torres MJ, Valenzuela FJ, Larraín R, Figueroa-Diesel H, Galaz J, Nien JK, Serra R, Michea L, Illanes SE.
Prenat Diagn. 2012 Aug 7:1-6. doi: 10.1002/pd.3954. [Epub ahead of print]
PMID: 22886584

Positive association between aldosterone-renin ratio and carotid intima-media thickness in hypertensive children.
Loureiro C, Campino C, Martinez-Aguayo A, Godoy I, Aglony M, Bancalari R, Garcia H, Carvajal CA, Fardella C.
Clin Endocrinol (Oxf). 2012 Jul 16. doi: 10.1111/j.1365-2265.2012.04503.x. [Epub ahead of print]
PMID: 22803613

IgG keeps virulent Salmonella from evading dendritic cell uptake.
Riquelme SA, Bueno SM, Kalergis AM.
Immunology. 2012 Jul;136(3):291-305. doi: 10.1111/j.1365-2567.2012.03578.x.
PMID: 22352313

M-protein gene-type distribution and hyaluronic acid capsule in group A Streptococcus clinical isolates in Chile: association of emm gene markers with csrR alleles.
Wozniak A, Rojas P, Rodríguez C, Undabarrena A, Garate C, Riedel I, Román JC, Kalergis AM, García P.
Epidemiol Infect. 2012 Jul;140(7):1286-95. Epub 2011 Sep 12.
PMID: 21906413

Respiratory syncytial virus infection and immunity.
González PA, Bueno SM, Carreño LJ, Riedel CA, Kalergis AM.
Rev Med Virol. 2012 Jul;22(4):230-44. doi: 10.1002/rmv.1704. Epub 2012 Jan 31.
PMID: 22290692

Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients.
Tittarelli A, González FE, Pereda C, Mora G, Muñoz L, Saffie C, García T, Díaz D, Falcón C, Hermoso M, López MN, Salazar-Onfray F.
Cancer Immunol Immunother. 2012 May 3. [Epub ahead of print]
PMID: 22552381

Birth weight is inversely associated with blood pressure and serum aldosterone and cortisol levels in children.
Martinez-Aguayo A, Aglony M, Bancalari R, Avalos C, Bolte L, Garcia H, Loureiro C, Carvajal C, Campino C, Inostroza A, Fardella C.
Clin Endocrinol (Oxf). 2012 May;76(5):713-8. doi: 10.1111/j.1365-2265.2011.04308.x.
PMID: 22145676

Overexpression of 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non-alcoholic fatty liver disease.
Candia R, Riquelme A, Baudrand R, Carvajal CA, Morales M, Solís N, Pizarro M, Escalona A, Carrasco G, Boza C, Pérez G, Padilla O, Cerda J, Fardella CE, Arrese M.
Liver Int. 2012 Mar;32(3):392-9. doi: 10.1111/j.1478-3231.2011.02685.x. Epub 2011 Dec 4.
PMID: 22136330

Bone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosis.
Macanas-Pirard P, Leisewitz A, Broekhuizen R, Cautivo K, Barriga FM, Leisewitz F, Gidi V, Riquelme E, Montecinos VP, Swett P, Besa P, Ramirez P, Ocqueteau M, Kalergis AM, Holt M, Rettig M, DiPersio JF, Nervi B.
PLoS One. 2012;7(5):e37203. Epub 2012 May 22.
PMID: 22629369

FcγRIIb and BAFF differentially regulate peritoneal B1 cell survival.
Amezcua Vesely MC, Schwartz M, Bermejo DA, Montes CL, Cautivo KM, Kalergis AM, Rawlings DJ, Acosta-Rodríguez EV, Gruppi A.
J Immunol. 2012 May 15;188(10):4792-800. Epub 2012 Apr 18.
PMID: 22516957

Functional and structural analysis of the internal ribosome entry site present in the mRNA of natural variants of the HIV-1.
Vallejos M, Carvajal F, Pino K, Navarrete C, Ferres M, Huidobro-Toro JP, Sargueil B, López-Lastra M.
PLoS One. 2012;7(4):e35031. Epub 2012 Apr 4.
PMID: 22496887

11β-hydroxysteroid dehydrogenase type 2 polymorphisms and activity in a Chilean essential hypertensive and normotensive cohort.
Campino C, Quinteros H, Owen GI, Carvajal CA, Morales M, Olivieri O, Guidi G, Faccini G, Pasini F, Baudrand R, Padilla O, Valdivia C, Thichauer J, Lagos CF, Kalergis AM, Fardella CE.
Am J Hypertens. 2012 May;25(5):597-603. doi: 10.1038/ajh.2011.263. Epub 2012 Jan 26.
PMID: 22278213

The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanism.
Vera-Otarola J, Solis L, Soto-Rifo R, Ricci EP, Pino K, Tischler ND, Ohlmann T, Darlix JL, López-Lastra M.
J Virol. 2012 Feb;86(4):2176-87. Epub 2011 Dec 7.
PMID: 22156529

Interplay between thermal and immune ecology: effect of environmental temperature on insect immune response and energetic costs after an immune challenge.
Catalán TP, Wozniak A, Niemeyer HM, Kalergis AM, Bozinovic F.
J Insect Physiol. 2012 Mar;58(3):310-7. Epub 2011 Oct 14.
PMID: 22019347

A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.
Carvajal CA, Campino C, Martinez-Aguayo A, Tichauer JE, Bancalari R, Valdivia C, Trejo P, Aglony M, Baudrand R, Lagos CF, Mellado C, Garcia H, Fardella CE.
Hypertension. 2012 Jan;59(1):85-91. Epub 2011 Nov 14.
PMID: 22083159

Evasion of host immunity by virulent Salmonella: implications for vaccine design.
Riquelme SA, Wozniak A, Kalergis AM, Bueno SM.
Curr Med Chem. 2011;18(36):5666-75. Review.
PMID: 22172071

Excision of an unstable pathogenicity island in Salmonella enterica serovar Enteritidis is induced during infection of phagocytic cells.
Quiroz TS, Nieto PA, Tobar HE, Salazar-Echegarai FJ, Lizana RJ, Quezada CP, Santiviago CA, Araya DV, Riedel CA, Kalergis AM, Bueno SM.
PLoS One. 2011;6(10):e26031. Epub 2011 Oct 19.
PMID: 22039432

Genetic and pharmacological modulation of dendritic cell-T cell interactions as a therapeutic strategy for systemic lupus erythematosus.
Llanos C, Carreño LJ, Gutierrez MA, Riedel CA, Jacobelli SH, Kalergis AM.
Curr Gene Ther. 2011 Dec;11(6):544-53. Review.
PMID: 22023471

Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-γ-producing NK cell and regulatory T cell subsets.
Aravena O, Pesce B, Soto L, Orrego N, Sabugo F, Wurmann P, Molina MC, Alfaro J, Cuchacovich M, Aguillón JC, Catalán D.
Immunobiology. 2011 Dec;216(12):1256-63. Epub 2011 Jul 7.
PMID: 21840621

Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and β cell dysfunction.
Baudrand R, Campino C, Carvajal CA, Olivieri O, Guidi G, Faccini G, Sateler J, Cornejo J, Martin BS, Dominguez JM, Cerda J, Mosso LM, Owen GI, Kalergis AM, Fardella CE.
Steroids. 2011 Dec 20;76(14):1575-81. Epub 2011 Oct 5.
PMID: 21996535

Overexpression of hepatic 5α-reductase and 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue is associated with hyperinsulinemia in morbidly obese patients.
Baudrand R, Domínguez JM, Carvajal CA, Riquelme A, Campino C, Macchiavello S, Bozinovic M, Morales M, Pizarro M, Solis N, Escalona A, Boza C, Arrese M, Fardella CE.
Metabolism. 2011 Dec;60(12):1775-80. Epub 2011 Jun 24.
PMID: 21704348

Aldosterone as a modulator of immunity: implications in the organ damage.
Herrada AA, Campino C, Amador CA, Michea LF, Fardella CE, Kalergis AM.
J Hypertens. 2011 Sep;29(9):1684-92. Review.
PMID: 21826023

Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation.
Mendoza-Naranjo A, Bouma G, Pereda C, Ramírez M, Webb KF, Tittarelli A, López MN, Kalergis AM, Thrasher AJ, Becker DL, Salazar-Onfray F.
J Immunol. 2011 Sep 15;187(6):3121-32. Epub 2011 Aug 15.
PMID: 21844382

Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity.
Llanos C, Carreño LJ, Kalergis AM.
Biol Res. 2011;44(1):53-61. doi: 10.4067/S0716-97602011000100007. Epub 2011 May 11. Review.
PMID: 21720681

A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-β+ tolerogenic dendritic cells.
López MN, Pesce B, Kurte M, Pérez C, Segal G, Roa J, Aguillón JC, Mendoza-Naranjo A, Gesser B, Larsen C, Villablanca A, Choudhury A, Kiessling R, Salazar-Onfray F.

Immunobiology. 2011 Oct;216(10):1117-26. Epub 2011 Apr 22.

PMID: 21601308

Activity of the human immunodeficiency virus type 1 cell cycle-dependent internal ribosomal entry site is modulated by IRES trans-acting factors.
Vallejos M, Deforges J, Plank TD, Letelier A, Ramdohr P, Abraham CG, Valiente-Echeverría F, Kieft JS, Sargueil B, López-Lastra M.

Nucleic Acids Res. 2011 Aug;39(14):6186-200. Epub 2011 Apr 10.
PMID: 21482538

Frequency of familial hyperaldosteronism type 1 in a hypertensive pediatric population: clinical and biochemical presentation.
Aglony M, Martínez-Aguayo A, Carvajal CA, Campino C, García H, Bancalari R, Bolte L, Avalos C, Loureiro C, Trejo P, Brinkmann K, Giadrosich V, Mericq V, Rocha A, Avila A, Perez V, Inostroza A, Fardella CE.
Hypertension. 2011 Jun;57(6):1117-21. Epub 2011 Apr 18.
PMID: 21502562

Infection of human monocyte-derived dendritic cells by ANDES Hantavirus enhances pro-inflammatory state, the secretion of active MMP-9 and indirectly enhances endothelial permeability.
Marsac D, García S, Fournet A, Aguirre A, Pino K, Ferres M, Kalergis AM, Lopez-Lastra M, Veas F.
Virol J. 2011 May 13;8:223.
PMID: 21569520

Modulation of the dendritic cell-T-cell synapse to promote pathogen immunity and prevent autoimmunity.
Carreño LJ, González PA, Bueno SM, Riedel CA, Kalergis AM.
Immunotherapy. 2011 Apr;3(4 Suppl):6-11. Review.
PMID: 21524159

Heat-shock induction of tumor-derived danger signals mediates rapid monocyte differentiation into clinically effective dendritic cells.
Aguilera R, Saffie C, Tittarelli A, González FE, Ramírez M, Reyes D, Pereda C, Hevia D, García T, Salazar L, Ferreira A, Hermoso M, Mendoza-Naranjo A, Ferrada C, Garrido P, López MN, Salazar-Onfray F.

Clin Cancer Res. 2011 Apr 15;17(8):2474-83. Epub 2011 Feb 3.

PMID: 21292818

Local cytokine response upon respiratory syncytial virus infection.
Bueno SM, González PA, Riedel CA, Carreño LJ, Vásquez AE, Kalergis AM.

Immunol Lett. 2011 May;136(2):122-9. Epub 2010 Dec 31. Review.

PMID: 21195729

Interleukin 10 decreases MICA expression on melanoma cell surface.
Serrano AE, Menares-Castillo E, Garrido-Tapia M, Ribeiro CH, Hernández CJ, Mendoza-Naranjo A, Gatica-Andrades M, Valenzuela-Diaz R, Zúñiga R, López MN, Salazar-Onfray F, Aguillón JC, Molina MC.

Immunol Cell Biol. 2011 Mar;89(3):447-57. Epub 2010 Aug 17.

PMID: 20714339

An ultrasound model to discriminate the risk of thyroid carcinoma.
Domínguez JM, Baudrand R, Cerda J, Campusano C, Fardella C, Arteaga E, Cruz F, Solar A, Arias T, Mosso L.

Acad Radiol. 2011 Feb;18(2):242-5. Epub 2010 Nov 13.

PMID: 21075018