Dra. Mónica Cáceres LLuch
Investigador Principal
P. Universidad de Chile
Líneas de Investigación
– Blancos moleculares asociados a la senescencia celular como sustrato para el diseño de senolíticos, senostaticos o senomorficos, enfocándonos en el mecanismo de la acumulación de las células senescentes durante el envejecimiento y como estas “se conectan” con macrófagos y células “natural killer”.
– Efectos del envejecimiento en la reparación de tejidos blancos como la piel y los tejidos periodontales y las respuestas celulares asociadas como migración, contracción y remodelación de la matriz extracelular.
Recientes Publicaciones del Laboratorio (últimos 10 años)
Gonzalez-Avendaño M, Zuñiga-Almonaicd S, Silva I, Lavanderos B, Robinson F, Rosales-Rojas R, Duran-Verdugo F, Gonzalez W, Caceres M, Cerda O, Vergara-Jaque A. PPI-MASS: an interactive web server to identify protein-protein interactions from mass spectrometry-based proteomics data. Frontiers Molecular Biosciences 2021 (8):701477.
Fernandez C, Burgos A, Morales D, Rosales-Rojas R, Canelo J, Vergara-Jaque A, Viliod Vieira A, Alberto Alves da Silva R, Uzzun Sales K, Conboy MJ, Bae EJ, Park KS,. Torres VA, Garrido M, Cerda O, Conboy IM, Cáceres M*. TMPRSS11a is a novel age-altered, tissue specific regulator of migration and wound healing. Faseb Journal 2021 35(5);e21597.
Saldías MP, Maureira D, Orellana-Serradell O, Silva I, Lavanderos B, Cruz P, Torres C, Cáceres M, Cerda O. TRP channels interactome as a novel therapeutic target in breast cancer. Frontiers in oncology 2021:11:621614.
Garrido M , Morales D, Saldías MP, Fernández C, Villalobos V, Cerda O, Cáceres M*. Cellular response of human apical papilla cells to calcium hydroxide and tricalcium silicate-based cements. BMC oral health 2021 21:106.
Torres P, Hernández N, Mateluna C, Silva P, Reyes M, Solano , Venegas S, Criollo A, . Bikker FJ, Nazmi K, Bolscher J, Garrido M, Cáceres M,. Torres VA. 2021. Histatin 1 is a novel osteogenic factor that promotes bone cell adhesion, migration and differentiation. Journal of Tissue Engineering and regenerative Medicine doi: 10.1002/term.3177.
Maldonado F, Morales D,Gutierrez R, Barahona M, Cerda O and Caceres M*. (2020). Effect of sevoflurane and propofol on tourniquet-induced endothelial damage: a pilot randomized controlled trial for knee ligament surgery BMC anesthesiology 20:121.
Rivas J, Diaz N, Silva I et al, Caceres M, Cerda O. KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis Faseb J 34(6):7847-7865.
Blanco, C., Morales, D., Mogollones, I., Vergara-Jaque, A., Vargas, C., et al. Cáceres M, Cerda O (2019). EB1- and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion. Faseb J, fj201900136R.
Saldías MP, Morgan A, Fernández C, Díaz C, Silva A, Jaña F, Gómez, Briceño F, Oyarzún A, Maldonado F, Cerda O, Smith PC, Cáceres C*. Aged blood factors decrease cellular responses associated with delayed gingival wound repair. PloS One,2017. 12(9), e0184189.
Retamal IN, Hernandez R, González-Rivas C, Cáceres M, Arancibia R, Romero A, Martinez J, Smith PC. (2016). Methylglyoxal and methylglyoxal-modified collagen as inducers of cellular injury in gingival connective tissue cells. J Periodontal Res 51(6):812-821.
Caceres, M., Ortiz, L., Recabarren, T., Romero, A., Colombo, A., Leiva-Salcedo, E., Varela, D., Rivas, J., Silva, I., Morales, D., Campusano, C., Almarza, O., Simon, F., Toledo, H., Park, K.S., Trimmer, J.S., Cerda, O. TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility. PLoS One 10 (2015), e0130540.
Smith, P. C., Martínez, C., Cáceres, M., & Martínez, J. (2015). Research on growth factors in periodontology. Periodontology 2000, 67(1), 234–250.
Smith, P. C., Cáceres, M., Martínez, C., Oyarzún, A., & Martínez, J. (2015). Gingival Wound Healing: An Essential Response Disturbed by Aging? Journal of Dental Research. 94(3), 395–402.
Cerda, O., Cáceres, M., Park, K.-S., Leiva-Salcedo, E., Romero, A., Varela, D., et al. (2015). Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca2+-activated non-selective cation channel TRPM4. Pflügers Archiv – European Journal of Physiology.
Cáceres, M.*, Oyarzún, A., & Smith, P. C. (2014). Defective Wound-healing in Aging Gingival Tissue. J Dent Res 93(7):691-697.