Dra. Claudia Riedel
Principal Investigator
Universidad Andrés Bello
Claudia Riedel Soria, Associate Professor at Universidad Andrés Bello, Biochemistry, Catholic University of Chile University, Doctor of the Albert Einstein College of Medicine of New York Science.
The interest of our laboratory is to study from molecular and cellular physiology, the role of iodide (I-) and thyroid hormones in mammals. The aim is to deliver knowledge aimed to prevent or treat disorders or thyroid-related diseases. Studies in our laboratory have contributed with evidence showing that progeny that developed a maternal environment with reduced levels of thyroid hormones, such as hypothyroidism or maternal hypothyroxinemia exhibit cognitive deficits (3). Our goal is to find molecular targets of thyroid hormones in order to reverse the cognitive impairment. We develop in vivo or in vitro models permitean we analyze the development of neurons establish synapses and astrocyte participation in these processes. Furthermore, our laboratory has found evidence showing that both hypothyroidism and gestational hypothyroxinemia conditioned to submit to the progeny as adults increased sensitivity and severity in inflammatory pathologies of the central nervous system (CNS) such as multiple sclerosis. Cellular and molecular alterations that caused the deficiency of thyroid hormones in this progeny once desrrolla inflammatory disease may suffer more inflammation adult CNS with greater intensity are unknown. Our laboratory is addressing this question from different angles. First, we are evaluating if the blood-brain barrier (BBB) of progeny gestated in mothers suffering from hypothyroidism or hypothyroxinemia is more permeable to the immune system than the euthyroid offspring. Moreover, we are studying the effect of thyroid hormone deficiency during pregnancy on the immune system of the offspring. In addition, we are evaluating survival and cell death of different cell types in the CNS as neurons, astrocytes, oligodendrocytes and microglia in multiple sclerosis, oxidative stress and / or TNF-alpha exposicón. These studies contribute evidence to discern the impact of hypothyroidism and gestational hypothyroxinemia on the progeny.
Thyroid hormones are essential for the functioning of all cells of the body and the I component is critical thereof. Our laboratory has developed a parallel line of research that studies the molecular mechanisms by I-capture mammals. The relevance of this research is in medicine as the capture molecule is the transporter I-Na + / I-(NIS) and is a target for gene therapy for treating cancer.
Members of the Laboratory:
– Henny Haensgen, Postodoctorante.
– Cecilia Opazo, Postdoctotante.
– Betsy Flores, Biochemist.
– Alejandro Arriagada, PhD thesis student
– Pablo Cisternas, PhD thesis student.
– Luis Venegas, PhD thesis student.
– Katherine Acevedo, tesista Biochemistry.
– Eduardo Albornoz tesista Biochemistry.
– Beatriz Alvarez, tesista Biotechnology.
– Pablo Gonzalez, tesista Biochemistry.
– Maximiliano Mitchell, student of Biochemistry
– Gonzalo Vidal, Biotechnology student.
– Gabriela Zuniga tesista Biochemistry.
Relevant Publications:
1 Riedel, C., Levy O., and Carrasco N. (2001). “Post-transcriptional regulation of the sodium / iodide symporter by thyrotropin.” Vol J Biol Chem. 276 pp. 21458-21463.
2.Riedel, C., Dohan, O., De la Vieja A, Ginter CS and Carrasco, N. (2001) “Journey of the iodide transporter NIS: from identification to molecular STI STI clinical role in cancer” TIBS 26 pp.490-496 Vol.
3 Opazo MC, Gianini A, F Ianelli, Azkcona G, Alarcon L, R Lizana, Nights V, Gonzalez PA, Porto M, Mora S, Rosenthal D, Eugenin E, Naranjo D, Good SM, Riedel Kalergis AM and AC “Maternal Hypothyroxinemia impairs Spatial Learning and Synaptic nature and function 11 in the Offspring” (2008) Endocrinology. 2008 Oct, 149 (10): 5097-106. Epub 2008 Jun 19 PMID: 18566112
4 HE González Leiva A, Tobar M, Böhmwald K, Tapia G, Torres J, Mosso LM, Good SM, Gonzalez PA, CA Kalergis Amand Riedel “Altered chemokine receptor expression in Papillary Thyroid Cancer” Thyroid Sep 2009; 19 (9): 957-65.
5. Cortes C, Eugenin E, Aliaga E, Carreño LJ, Good SB, Gonzalez P, Gayol S, Naranjo D, Nights V, Marassi MP, Rosenthal D, Jadue C, Ibarra P, Keitel C, Wohllk N, Court F, Kalergis AM, Riedel CA “Hypothyroidism in the adult rat causes an increment of BDNF in the brain, neuronal and astrocyte apoptosis, gliosis and deterioration of the postsynaptic density.” Thyroid. 2012 May 16.
RESEARCH EXPERIENCE
1 Master Thesis in Neuropharmacology:
“The uptake of noradrenaline in the bed of the stria terminalis after injuries Noradrenergics way.” (1993-1994)
2 Research Laboratory in reproduction and embryogenesis in mice, chicken and hamster (March to August 1996).
3 Laboratory research on the renal circulation in rats (September to January 1996).
4 Ph.D. Molecular Pharmacology Thesis: “Post-transcriptional regulation of the thyroid Na + / I-symporter (NIS) by thyrotropin.” (1996-2002)
Line 5. research on the effects of iodine deficiency, hypothyroxinemia and hypothyroidism in the central nervous system (in progress).
6 Identification of iodide carrier mice Auslicomys boliviensis (ongoing).
7 Evaluation, in rodents, the side effects of Coxsal a replacement for salt in the diet (2008)
8 Participation FONDEF # D04l1075 project for detection of respiratory syncytial virus (RSV) and the development of a vaccine to eliminate virus. Researcher: Dr. Alexis Kalergis (completed).
FONDEF Sharing project 9, # D06I1008 to develop a kit for the detection of the respiratory syncytial virus (RSV). Responsible researcher: Dr. Alexis Kalergis (ongoing).
10 Participation in INCO project to develop new therapeutic and prophylactic strategies for the control of mucosal infections by bacterial South American strains “Coordinator: Dr. Alexis Kalergis (finished).
Educational Experience
1 – Thesis Director Mrs undergraduates Angela Gianini (2004-2006)..
2 – Thesis director of undergraduate Claudia Cortés (2005-2007)..
3 – Chief Master of Science thesis of Ms. Cecilia Opazo student (2006-2008)..
4 – Director of Master of Science thesis of Mr. Hugo Tobar student (2006-2008).
5 – Thesis Director of Pharmaceutical Chemistry Ms.Gianella Segovia (2009).
6 – Director, Master of Science thesis of Ms. Karen Bohmwald student (2009-2010).
7 – Director, Master of Science Thesis, student Eduardo Albornoz (ongoing).
8 – Thesis director doctoral student Alejandro Arriagada (ongoing).
9 – Head of Doctoral Dissertation. Mr. Paul Student Tanker (ongoing).
10 Director of Master of Science Thesis, Mr. student Pablo González (ongoing).
11 Thesis Director Master of Science student Ms. Gabriela Zuniga (ongoing).
12 Thesis Director Master of Science student Ms. Katherine Acevedo (ongoing).
13 Director of Engineering Thesis in Biotechnology, Ms.. Beatriz Alvarez (ongoing).
14 Thesis director of a student doctoral program Molecular Sciences UNAB Mr. Luis Venegas (ongoing).
Guest speaker (seminars) – Zoological Station “Anton Dohrn”, Naples, Italy. June 2000.
– Institute of Nutrition and Food Technology (INTA), Chile November 2002.
– Pontifical Catholic University of Chile, Department of Physiology July 2003.
– Institute of Nutrition and Food Technology (INTA), Chile April 2004.
– University of Tarapaca, Arica Chile in July 2004
– University of Chile, Faculty of Science, April 2005.
– Pontifical Catholic University of Chile, FONDAP, June 2005.
– Andrés Bello University, July 2005.
– Meeting of Students of Biochemistry, August 2005.
– Symposium: “Role of iodine and maternal thyroid hormones in Development of the Nervous System of His Son”, Santiago de Chile October 2005.
– Symposium II: “By Neurotrophin-mediated signaling. Molecular, cellular and physiological aspects, “Made in The First Congress of the Chilean Society for Neuroscience, Santiago Chile in December 2005.
– Autonomous University of Mexico, Querétaro Neuroscience Institute, May 2006
– Department of Molecular Pharmacology, Albert Einstein College of Medicine, October 2006
– Iodine metabolism transport thyroid hormone synthesis and metabolism. Pre-Congress Course: “The molecular basis of the cognitive processes that are under the control of thyroid hormones.” Latin American Symposium of the Society of thyroid XII Congress April 27 to 30, 2007 Sheraton Hotel Santiago Chile
– Meeting of Students of Biochemistry, August 2007.
– Symposium on Developmental Neurobiology at the University of Valparaíso Chile August 30, 2007
– FONDAP for Molecular Studies of the Cell, University of Chile April 10, 2008.
– Symposium on Medicine Endocrinology, Pablo Neruda Hotel 23, May 24, 2008.
– Lautaro School, October 2008.
– Albert Einstein College of Medicine, Department of Molecular Pharmacology, January 2009.
– Meeting LATS, Gramado Brazil May 2009.
-mount Sinai, Department of Immunology, Oncological Sciences and Dermatology July 2009.
¶Memorial Sloan-Kettering Cancer Center, Human Oncology and Pathogenesis Program July 2009.
– University College London, Research Department of Cell and Developmental Biology, January 2010
-Unit 643 INSERM, Nantes February 2010.
– Sloan Kettering, New York July 2010.
-mount Sinai Medical Center, Icahn Medical Institute, NY July 2010.
-Simposio LATS, Peru Lima August 2011.
– UNAB Symposium, Santiago Chile November 2011.
– Society for Cell Biology Symposium Puerto Varas Chile November 2011.
– Seminar of the Catholic University of Chile MINFAB, March 2012
– Capsules of Knowledge Seminar, May 2012
– International Symposium SOCHED June 2012.
Publications1. Levy, O., Dai G, Riedel C, Ginter CS, EM, P., Lebowitz, AN and Carrasco, N. (1997) “Characterization of the thyroid Na + / I-symporter with one “Proc. anti-COOH terminal antibody. Natl. Acad. Sci. USA .. Vol. 94, pp 5568-5573.
2 Levy, O., De la Vieja A, Ginter CS, Riedel, C., Dai, G., and Carrasco, N. (1998) “N-linked glycosylation of the thyroid Na + / I-symporter (NIS) Implications for its secondary structure model “J Biol Chem. vol. 273 pp 22657-22663.
3 Riedel, C., O. Levy and N. Carrasco (2001). “Post-transcriptional regulation of the sodium / iodide symporter thyrotropin.” J Biol Chem. Vol. 276 pp 21458-21463.
4 Riedel, C., Dohan, O., De la Vieja A, Ginter CS and Carrasco, N. (2001) “Travel iodide transporter NIS: from its molecular identification to its clinical role in the cancer “TIBS pp.490-496 Vol 26.
5 Park, DS, Lee, H., Riedel, C., Hulit, J., Scherer, PE, Pestell RG, Lisanti, MP (2001) “Prolactin negatively regulates caveolin-1 gene expression in the gland breast during lactation through a Ras-dependent mechanism. “J Biol Chem. vol. 276 pp 48389-48397.
6 Xhang, X., Riedel, C. Carrasco. N. and Arvan, P. (2002) “Traffic polarized thyrocyte proteins in MDCK cells.” Mol. Cell Endocrinol 188 (1-2) 27-36.
7 Dohan, O., De la Vieja, A., Paroder, V., Riedel, C., Artani, M. Reed, M., Ginter, CS and Carrasco, N. (2003) ¨ The sodium / iodide symporter (NIS): Characterization Significance, regulation and Medical ¨ Endocr. Rev. 24 (1): 48-77.
8 Good SM, Gonzalez PA, Pacheco R, Lewis ED, KM Wow, Tobar HE, JE Mora, CE Prado, JE Zuniga, Jimenez J, Riedel CA, and Kalergis AM. “Host immunity during RSV pathogenesis” (2008) Int. Immunopharmacol. October; 8 (10): 1320-9.
9 Iruretagoyena MI, Riedel CA, ED Lewis, MA Gutiérrez, SH Jacobelli and Kalergis AM “Enabling and recetors differentially inhibit Fc gamma can modulate T cell-mediated autoimmunity” (2008) Eur. J. Immunol. August; 38 (8): 2241-50.
10 Opazo MC, Gianini A, Ianelli F, G Azkcona, Alarcon L, R Lizana, Nights V, Gonzalez PA, Porto M, Mora S, D Rosenthal, Eugenin E, Naranjo D, Good SM, AM and CA Kalergis Riedel. “Maternal hypothyroxinemia affects spatial learning and 11 Nature and synaptic function in the lineage” (2008) Endocrinology. October 2008, 149 (10): 5097-106. Epub 2008 Jun 19 PMID: 18566112 [
12 González PA, CE Prado, ED Lewis, LJ Carreño, SM Well, CA Riedel, Kalergis AM. “Respiratory syncytial virus affects T-cell activation by preventing assembly synapses with dendritic cells.” (2008) Proc Natl Acad Sci USA A. September 30, 105 (39): 14999-5004. Epub 2008 September 25. PMID: 18818306
13 Good SM, PA Gonzalez, KM Captive, JE Mora, ED Leiva, Tobar HE, Fennelly GJ, EA Eugenin, WR Jacobs, CA Riedel and Kalergis AM. Protective immunity of T cells from RSV is efficiently by recombinant BCG (2008) PNAS 30 December induced; 105 (52): 20822-20827.
Kalergis 14 AM, Iruretagoyena MI, MJ Barrientos, PA González, AA Herrada, ED Leiva, Gutierrez MA, Riedel CA, Good SM, SH Jacobelli. Modulation of nuclear factor-kappaB activity may influence susceptibility to systemic lupus erythematosus. Immunology. 7 November 2008 Published online DOI: 10.111 / J.1365-2567.2008.02964.
15 González HE, Leiva A, H Tobar, Böhmwald K, G Tapia, J. Torres, Mosso LM, SM Well, PA González, CA Kalergis Amand Riedel “Altered expression of chemokine receptor in papillary thyroid cancer” 2009 thyroid Sep; 19 (9): 957-65.
Well PA 16 Gonzalez SM, CA Riedel and Kalergis AM. Impaired immunity by T cells respiratory syncytial virus: targeting virulence mechanisms for therapy and prophylaxis. Current Medicinal Chemistry 2009 Curr Med Chem 16 (34):. 4609-25.
Herrada 17 AA, FJ Contreras, Marini NP, CA Amador, PA González, CM Cortés, CA Riedel, Carvajal CA, Figueroa F, LF Michea, CE Fardella, Kalergis AM. Aldosterone promotes autoimmune damage by improving Th17 mediated immunity. 2010 J Immunol. January 1; 184 (1): 191-202.
18 LJ Carreno, EM Riquelme, PA González, N Espagnolle, CA Riedel, Valitutti S, Kalergis AM. “Antagonism of T cells for short half-life pMHC ligand may be mediated by an efficient T cell capture bias towards APC”. 2010 Proc Natl Acad Sci USA A. January 5; 107 (1): 210-5.
19 Good SM, Riedel CA, LJ Carreño, Kalergis AM. “Mechanisms Salmonella virulence shown alter function of dendritic cells,” Curr Med Chem 2010. 17th February.
20 LJ Carreño, CA Riedel and Kalergis AM. 2010 “The induction of tolerogenic dendritic cells by blocking NF-kB and modulation of Fc gamma receptor.” . Methods Mol Biol, 677:. 339-53 PMID: 20941620
21 Good SM, Wozniak A, Leiva ED, Riquelme SA, LJ Carreño, Hardt WD, CA Riedel, Kalergis AM. 2010 “Salmonella pathogenicity island 1 differentially modulates the entry of bacteria to the dendritic cells and not fagocítica-“. . Immunology June 1; 130 (2): 273-87 PMID: 20201987.
Araya 22 DV, TS Quiroz, HE Tobar, Lizana R, Quezada C, Santiviago CA; Riedel CA, Kalergis AM and Good S. “Deleting a prophage-like element causes attenuation of Salmonella enterica serovar Enteritidis and promotes protective immunity”. Vaccine 2010 June 14 Epub ahead of print PMID: 20558245.
Captive 23 KM, Good SM, Cortes CM, Wozniak A, Riedel CA, Kalergis AM. 2010 “Recruitment efficient pulmonary respiratory syncytial virus-specific Th1 cells by recombinant Bacillus Calmette-Guerin induced virus removal promotes and protects against infection,” J Immunol. November 17. Epub ahead of print PMID: 21084664.
24 González PA, SM Well, LJ Carreño, CA Riedel, Kalergis AM. “The respiratory syncytial virus infection and immunity” Rev Med Virol. 31 Jan 2012 doi: 10.1002 / rmv.1704. [Epub ahead of print] PMID: 22290692
25 TS Quiroz, PA Nieto, Tobar HE, Salazar-Echegarai FJ, RJ Lizana, CP Quezada, CA Santiviago, DV Araya, CA Riedel, AM Kalergis, SM Bueno. “Excision of an unstable pathogenicity island of Salmonella enterica serovar Enteritidis is induced during infection of phagocytic cells.” PLoS One 2011.; 6 (10): e26031. Epub 2011 Oct 19 PMID: 22039432
26. Llanos C, LJ Carreño, Gutierrez MA, Riedel CA, Jacobelli SH, Kalergis AM. “Pharmacological modulation of gene interactions and dendritic cells T cells as a therapeutic strategy for systemic lupus erythematosus.” Curr Gene Ther. 2011 Oct 21; 11 (6). [Epub ahead of print]
PMID: 22023471
27 LJ Carreño, González PA, Good SM, Riedel CA, Kalergis AM. “Modulation of dendritic cells to the T cell synapse promote immunity to pathogens and prevent autoimmunity.” Immunotherapy. 2011 Apr; 3 (4 Suppl): 6-11. Review.PMID: 21524159
28 Good SM, PA González, CA Riedel, LJ Carreno, AE Vasquez Kalergis AM. “The local cytokine response to respiratory syncytial virus.”
Immunol Lett. May 2011; 136 (2): 122-9. Epub 2010 December 31. Look over.
PMID: 21195729.
29 Gonzalez PA, Good SM, LJ Carreño, CA Riedel, Kalergis AM. “The respiratory syncytial virus infection and immunity.” Rev Med Virol. 2012 Jan
31 doi: 10.1002 / rmv.1704. [Epub ahead of print].
30 Cortés C, Eugenin E, Aliaga E, LJ Carreño, SB Well, González P, S Gayol, Naranjo D, V Nights, Marassi MP, Rosenthal D, Jadue C, P Ibarra, Keitel C, N Wohllk, Track F, Kalergis AM, Riedel CA “Hypothyroidism in adult rats causes an increase of BDNF in brain, neuronal apoptosis and astrocyte gliosis and the deterioration of the postsynaptic density”.
Thyroid. 2012 May 16. [Epub ahead of print]
communications
Eduardo Albornoz1, 3, Claudia Cortes1, 3 Paul Cisternas1, 3 Paul Gonzalez1, 3, Carlos Pizarro1, 3, Leandro Carreño2, 3, Susan Bueno2, 3, Elisha Eugenin4, Joan Berman4, Kalergis2 Alexis, 3, and Claudia Riedel1, 3
1Facultad of Biological Sciences, Universidad Andrés Bello. 2 Department of Molecular Genetics and Microbiology, Faculty of Biological Sciences, PUC. Millennium 3Instituto Immunology and immunotherapy. 4Albert Einstein College of Medicine in New York.
“Assessment of the viability of oligodendrocyte progeny gestated in mothers with thyroid hormone deficiency in response to inflammatory molecules.”
Annual Society of Cell Biology Chile 1st to 5th November 2011 Port of Varas Chile.
Pablo Cisternas 1.2 *, 1.2 * Pablo González, Gabriela Zuniga * 1.2, 1.2, 1.3 1.3 Claudia Cortés Susan Leandro Carreño Well, Alexis Kalergis 1,3,4, 1,2 Claudia Riedel.
1Millennium Institute of Immunology and Immunotherapy. 2Faculty of Biological Sciences, Universidad Andrés Bello. 3Department of Molecular Genetics and Microbiology, Faculty of Biological Sciences. Pontifical Catholic University of Chile. 4Department of Rheumatology, Faculty of Medicine. Pontifical Catholic University of Chile. * The authors contributed equally to this work.
“The thyroid hormone deficiency causes alterations in MATERNAL neurons and astrocytes in their children”
Annual Society of Cell Biology Chile 1st to 5th November 2011 Port of Varas Chile.
ARRIAGADA, A.1, BECERRA, A.2, MIRANDA, C.1, PLAZA, A.1, SIMON, F.2, GOOD, S.3, Kalergis, A.3, CARRASCO, N.4, RIEDEL, C.1.
1Laboratorio of Cell Biology and Pharmacology. Universidad Andrés Bello.
2Laboratorio of Cellular and Molecular Pathophysiology. Universidad Andrés Bello.
3Millennium Institute of Immunology and Immunotherapy. Department of Microbiology and Molecular Genetics. Pontifical Catholic University of Chile.
4Department of Molecular Pharmacology, Albert Einstein College of Medicine, USA ..
Iodide (I) induces rapid inhibition of Na + / I-symporter (NIS) Through ROS
Annual Society for Biochemistry and Molecular Biology 30 September 2011 Chile Valdivia. A. Janyra Espinoza1, 2, Paul F. Céspedes1, Claudia M. Cortés3, Roberto S. gomez1, Claudia and Alexis M. Riedel3 Kalergis1, 4, *.
1Millennium Institute of Immunology and Immunotherapy. Department of Molecular Genetics and Microbiology, Faculty of Biological Sciences. Pontifical Catholic University of Chile. 2Pontificia Catholic University of Valparaiso, 3Millennium Institute of Immunology and Immunotherapy. School of Biological Sciences U. Andrés Bello. 4Department of Rheumatology, Faculty of Medicine. Pontifical Catholic University of Chile
“Respiratory syncytial virus infection in the central nervous system”
Annual Society for Biochemistry and Molecular Biology 30 September 2011 Chile Valdivia.
Roberto S. gomez1, Jorge E. Mora1, Claudia M. Cortés3, Claudia A. Riedel3, Marcela V. Ferrés2, Susan M. and Alexis M. Bueno1 Kalergis1, 4, *
1Millenium Institute of Immunology and Immunotherapy, Department of Molecular Genetics and Microbiology, School of Biological Sciences and 2Center for Medical Research, Faculty of Medicine Pontifical Catholic University of Chile. 3Millenium Institute of Immunology and Immunotherapy, Department of Biological Sciences, Faculty of Biological Sciences and School of Medicine University Andrés Bello. 4Department of Rheumatology, Faculty of Medicine, Pontificia Universidad Católica de Chile.
“Detection of respiratory syncytial virus in cells and clinical samples by using three new monoclonal antibodies”
Annual Society for Biochemistry and Molecular Biology 30 September 2011 Chile Valdivia.
1Karen Bohmwald, Leiva 1Andrea, Riquelme 2Erick, Veliz 2Loreto, Kalergis 3Alexis, Riedel 1Claudia and Gonzalez 2Hernán
1Facultad of Biological Sciences, Universidad Andrés Bello, Santiago, Chile.
2 Department of Surgical Oncology, Catholic University of Chile, Santiago, Chile
3 School of Biological Sciences, Pontifical Catholic University of Chile Santiago, Chile
A study of CXCR3 and CXCL10 in papillary thyroid cancer
Annual Society of Cell Biology Chile 1 al 5 November 2010 Pucon Chile.
1.2 Captive M. Kelly, Claudia M. 1Cortes 1,2,3, Eduardo Albornoz, 1Paul Gonzalez 2Camila Lopez 2Leandro J. Carreño, M. 2Alexis Kalergisand, 1,3 Claudia A. Riedel.
1Facultad of Biological Sciences, Universidad Andrés Bello. 2 Department of Molecular Genetics and Microbiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile. 3Millennium Core Immunology and Immunotherapy.
“The thyroid hormone deficiencies during pregnancy increases susceptibility to develop EAE in children.”
Annual Society of Cell Biology Chile 1 al 5 November 2010 Pucon Chile.
1Arriagada A, 1Miranda C., 1Navarro C, 2Bueno S, 1Molina A, B 3Gompert, 4Valenzuela M, 4Cabello G, 5Carrasco N, 2Kalergis A, 1Riedel, C.
1University Andrés Bello. 2Pontificia Catholic University of Chile. 3University College of London. 4University of Tarapaca. 5Albert Einstein College of Medicine.
“Cloning and characterization of symporter Auliscomys boliviensis sodium iodide” annual meeting of the Society for Cell Biology Chile 1 al 5 November 2010 Pucon Chile.
1Bohmwald K, 1Leiva A, 1Vidal G, H 2González, 3Kalergis AM, 1Riedel CA1-Universidad Andrés Bello.2Department of Surgical Oncology, Catholic University of Chile. 3 Department of Molecular Genetics and Microbiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile. “Chemokine receptors in thyroid cancer” 9th Latin American Congress of Immunology, Viña del Mar, Chile November 3 – 7, 2009
1Arriagada A, 1Albornoz E, 2Bueno S, A and C. 1Riedel 2Kalergis 1Laboratorio Cellular Biology and Pharmacology. Universidad Andrés Bello. Microbiology 2Laboratorio Pontifical Catholic University of Chile. “Regulation of the function of NIS expression and iodide in thyroid cells” XXIII Annual Meeting of the Society for Cell Biology Chile 1 al 5 November 2009 Pucon Chile.
1González HE, 4Leiva A, 3Tobar H, K 4Bohmwald, 1Tapia K, 2-3Kalergis AM, AC 4Riedel
1-2-3Pontificia Chile.4Universidad Catholic University Andrés Bello. “Altered expression of CCR3, CCR7 and CXCR4 in papillary thyroid cancer” XIII Latin American Congress on Thyroid, April 30-May 3 in Gramado, Brazil. P135 page S217
1Opazo C, 1Gianini A, 2Pancetti F, 3Eugenin E, 4Mora S, 5González P, V 1Noches, 6Naranjo D, 5Kalergis AM, 1Riedel C. 1University Catholic University Andrés Bello.2 Norte.3Albert Einstein College of medicine.4Universidad of Chile. 5University of Valparaiso. “Maternal hypothyroxinemia deterioration Learning Space and Nature of synaptic ACTIVITY” XXII Annual Meeting of Cell Biology Congress Pucon 5.9 October 2008, page 20.
1Leiva A, H 2Tobar, 1Bohmwald K, G 2Tapia, HE 2González, 2Kalergis AM, AC 1Riedel 1University Andrés Bello.2Pontificia Catholic University of Chile. “Expression and Localization Chemokine receptor CCR3 in papillary thyroid cancer” XXII Annual Meeting of Cell Biology Congress Pucon 9.5 October 2008 P139 page 74.
1Opazo C, 1Alarcón L., 1Lizana R., S. 2mora, 1Riedel C 1University Andrés Bello. 2University of Chile. “Correlation between spatial memory and expression of c-jun and c-fos in rats gestated in mothers hipotiroxinémicas” XXI Annual Meeting of Cell Biology Congress Pucon 10.7 2007.P178 page 84.
1Tobar H., K. 1Böhmwald, H. 2Gonzalez, C. 1Riedel, 2Kalergis A. Andrés Bello National 1University. Department of Molecular Genetics and Microbiology, Faculty of Biological Sciences PUC2.“Expresión y Localización de receptores de quimioquinas en Células tumorales del Cáncer papilar de tiroides” XXI Reunión Anual de Biología Celular Congreso 7-10 de Pucón 2007. P (107) page 63.
1Cortés C., P. 1Ibarra, C. 1Pinto, 2Perez de Arce K., A. 2Alvarez, E. 3Eugenin, E. 4Aliaga, 1Riedel C. Universidad Andrés Bello. Catholic University of Chile.Albert Einstein College of Medicine, Nueva York, EE.UU., Universidad de Valparaíso.“Caracterización de las DPS de las neuronas del telencéfalo de ratas hipotiroideas” XXI Reunión Anual de Biología Celular Congreso 7-10 de Pucón 2007. P (111) Página 64
H.González1, A Leiva; H1. Tobar2, C. Riedel2; Un Kalergis1. Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas PUC1. Departamento de Ciencias Biológicas y Farmacología UNAB2. “Expresión y Localización de receptores de quimioquinas en Células tumorales del Cáncer papilar de tiroides” Latin American Thyorid Sociedad XII Reunión. 7-30 de Abril 2007 Hotel Sheraton Santiago Chile. P126
FJ FLORES1, S. MORA1, OPAZO2 C, JADUE2 C, VALDES2 C, Pancetti F3, C. RIEDEL2; 1Universidad de Chile, 2Andres Bello University, Ciencias 3Biological, Universidad Católica del Norte, Coquimbo3. Perjudicial daño observado en la sinapsis glutamatérgica hipocampo de ratas adultas debido a la hipotiroxinemia materna durante su gestación Reunión Americana de Neurociencias 2006 Atlanta
1Arriagada A., C. 1Navarro, 1Molina A, B 2Gompert, 3Valenzuela M, 3Cabello G, 4Carrasco N, 1Riedel C, IDENTIFICACION Y DEL CLONAMIENTO ADNc QUE PARA EL codificación SIMPORTER Na + / I-(NIS) De La tiroides DEL AULISCOMYS roedor boliviensis 1Universidad Andrés Bello, 2 University Collage London, 3Universidad de Tarapacá, Albert 4Einstein Collage de Medicina. XX Congreso de la Sociedad de Biología Celular de Chile, Pucón 8-12 Octubre 2006.
1Cortes C., E. 1Morales, D 2Naranjo, C. 1Riedel, ESTUDIO DE LA COMPOSICIÓN Y LOCALIZACION DE LAS Proteínas sinápticas GLUTAMATERGICAS Y ES EL ANIMAL GABAERGICAS HIPOTIROIDEO 1Universidad Andrés Bello, 2Universidad de Valparaíso. XX Congreso de la Sociedad de Biología Celular de Chile, Pucón 8-12 Octubre 2006.
1Opazo C., C. 1Valdes, 1Irarrázabal J, 1Jadue C, 1Riedel C., LA MATERNA HIPOTIROXINEMIA AFECTA LA CITOARQUITECTURA NEURONAL DEL HIPOCAMPO 1Universidad Andrés Bello, XX Congreso de la Sociedad de Biología Celular de Chile, Pucón 8-12 Octubre 2006.
1Arriagada A, 1Navarro C, 1Valdés C, 2Valenzuela M, 2Cabello G, 1Molina A, B y 3Gompert 1Riedel C. 1Aislamiento y Caracterización del gen codificante del transportador de yodo de la tiroides del roedor Auliscomys boliviensis del altiplano andino. (Aislamiento y caracterización del gen que codifica para el cotransportador de yodo de la tiroides boliviensis Aulyscomis del altiplano andino) Universidad Andrés Bello, 2Universidad de Tarapacá, 3Universidad Collage London Reunión anual de la Sociedad de Bioquímica y Biología Molecular 6 de Enero del 2006.
Gianini A1., Pancetti F.2, Garikoitz A.3, C.1 Opazo, Mora y S.4 Riedel C.1. “La hipotiroxinemia Materna provocación Dano un su progenie neuronal” 1Universidad Andrés Bello, 2Universidad Católica del Norte, 3Universidad del País Vasco, España, 4Universidad de Chile. 1er Congreso Chileno de Neurociencias, 1 y 2 de Diciembre del 2005 Colegio Médico Santiago de Chile. CP25.
Cortés C., C. Jadue, V. Noches, S. Gallo, D. Naranjo y Riedel C “En el hipotirodismo BDNF inhibe la ACTIVIDAD del receptor NMDA de” Departamento de Ciencias Biológicas, Facultad de Ciencias de la Salud, Universidad Andrés Bello. 1er Congreso Chileno de Neurociencias, 1 y 2 de Diciembre del 2005 Colegio Médico Santiago de Chile. CP14.
Riedel, Claudia; Sandoval, Mauricio; Gianini, Angela; Rosenthal, Doris; Wohllk, Nelson “cambios estructurales y funcionales en las densidades postsinápticas del telencéfalo de hipotiroidismo”. 13 º Congreso Internacional de Tiroides, Buenos Aires Argentina Octubre 30 al 04 de noviembre 2005. Oral.
Cortés C., C. Jadue, V. Noches, S. Gallo, D. Naranjo y Riedel C “En el hipotirodismo BDNF inhibe la ACTIVIDAD del receptor NMDA de” Departamento de Ciencias Biológicas, Facultad de Ciencias de la Salud, Universidad Andrés Bello. Congreso de la Sociedad de Biología de Chile, Pucón 16-20 Octubre 2005.
Gianini A1., Pancetti F.2, Garikoitz A.3, C.1 Opazo, Mora y S.4 Riedel C.1. “La hipotiroxinemia Materna provocación Dano un su progenie neuronal” 1Universidad Andrés Bello, 2Universidad Católica del Norte, 3Universidad del País Vasco, España, 4Universidad de Chile. Congreso de la Sociedad de Biología de Chile, Pucón 12-16 Octubre 2005.
Sandoval M, Gianini A, Orrego F, U y Wyneken Riedel C. “El Hipotiroidismo causa Una disminución Específica de los receptores NR1, NR2AB y TrkB en las densidades postsinápticas del telencéfalo de rata”. Congreso de la Sociedad de Biología Celular de Chile, Pucón 13-17 Octubre 2004.
Gianini A, M Sandoval, Orrego F, U y Wyneken Riedel C. “La Hipotiroxinemia Materna modificación la Expresión de BDNF y TrkB en el telencéfalo de la Progenie”. Congreso de la Sociedad de Biología Celular de Chile, Pucón 13-17 Octubre 2004.
Riedel C, V. Paroder y Carrasco N. ¨ Reglamento de Na + / I-symporter (NIS) en la celda del Cáncer Mamario y de mama ¨. Época de Esperanza 2002 del Departamento de Defensa de mama Reunión del Programa de Investigación del Cáncer. Orange County Convention en Orlando Florida. 25 a 28 septiembre, 2002.
Riedel C, O Levy, De la Vieja A, Dohan O, C. Ginter y Carrasco N. “Reglamento de Na + / I-symporter (NIS) por la hormona estimulante del tiroides (TSH)” Conferencia sobre Gordon Proteínas de Transporte de Membrana: fisiológica y Implicaciones fisiopatológicas. Connecticut College, New London, CT. 22 a 27 julio, 2000.
Riedel C, De la Vieja A, Ginter CS, O Levy y Carrasco. “TSH regulación de la tiroides symporter yoduro (NIS)”. Segundo simposio AAPS Frontier: transportadores de membrana y el tratamiento farmacológico. Instituto Nacional de Salud, Bethesda, 1998.
Riedel C, O. y N. Levy Carrasco “Caracterización molecular y la regulación de la tiroides Na + / I-symporter”. Albert Einstein College of Medicine Una Presentación Simposio del primer Premio Anual de Investigación Julius Marmur, 1997.
O Levy, Ginter CS, De La Vieja A, G Dai, C. Riedel y Carrasco N. “N-glicosilación de la tiroides Na + / I-symporter (NIS). 70a Reunión Anual de la Asociación Americana de la Tiroides, Colorado Springs, Colorado, 1997. (P27)
O Levy, Dai G, C. Riedel y N. Carrasco “Caracterización molecular y la regulación de la tiroides Na + / I-symporter.” Asociación 69a reunión de la American Thyroid, San Diego California 13 a 17 noviembre, 1996. (121).
Cargo actual: Desde marzo de 2005 Profesor Asociado en el Departamento de Ciencias Biológicas de la Facultad de Ciencias Biológicas. Universidad Andrés Bello.
Posición anterior: Investigador Asociado Universidad de los Andes 2003-2004.
EDUCACIÓN
1988-1995 Maestría en Bioquímica, P. Universidad Católica de Chile.
1996-1998 Maestría en Ciencias, Albert Einstein College of Medicine.
1998-2002 Doctorado en Farmacología, en el laboratorio de la Dra. Nancy Carrasco en el Departamento de Farmacología Molecular, Albert Einstein College of Medicine de Nueva York EE.UU..
Honores Premios y Becas
1. Pre-doctorales pasantías, becas de desarrollo profesional. Ejército de Estados Unidos la investigación médica y la Oficina Material de comandos de los Programas de Investigación Médica dirigido el Congreso el año fiscal 1999 el cáncer de mama Programa de Investigación. El título del proyecto: “Regulación de la I-Transporte en líneas celulares de cáncer de mama”
2. Gordon Conferencia sobre Proteínas de Transporte de Membrana: Implicaciones fisiológicas y fisiopatológicas. Connecticut College, New London, CT. 22 a 27 julio, 2000. Comunicación: Riedel C, O Levy, De la Vieja A, Dohan O, C. Ginter y Carrasco N. “Reglamento de Na + / I-symporter (NIS) por la hormona estimulante de la tiroides (TSH)”
3. Regular FONDECYT 1040349 # (2004-2007).
“Estudio de los Efectos de la ingesta deficiente en I-Durante la gestación y lactancia Sobre:
I. La neurotransmisión excitadora y la Expresión de neurotrofinas en la corteza cerebral e hipocampo.
II. La Expresión del transportador de Na + / I-(NIS) en glándula mamaria y la placenta “.
4. Universidad Andrés Bello # DI-01-05R, (2005-2007)
“Análisis molecular del MECANISMO Que subyace la Acción inhibitoria de BDNF Sobre la ACTIVIDAD del receptor NMDA de cerebro proveniente del hipotiroideos de Animales”
5. Caridad Donación Dr.Bastian Gompert (en curso, 2005-2010).
“Identificación y clonación de la symporter natrium / yoduro (NIS) a partir de la tiroides de la bolieviensis Aulyscomis”
6. Universidad Andrés Bello # DI-44-08 / R (2008-2009) “Análisis del Efecto de la hipotiroxinemia Materna, en la progenie, Sobre las Estructuras dendríticas de las neuronas hipocampales y Sobre La Expresión de factors de Transcripción en Respuesta al aprendizaje” .
7. Regular FONDECYT 1100926 # (2010-2012) “hipotiroxinemia materna aumenta la susceptibilidad a desarrollar desmielinización inflamatoria en la descendencia”.
8: Instituto Milenio de Inmunología e inmunoterapia P-09-016F (2011-2016).
9. ECOS-CONICYT # C11S03. “El papel de CD3zeta en la alteración de la conectividad neuronal a partir de animales gestados en madres hypothyroxinemic”. (2012-2014).
10. Núcleo-UNAB # “Mitocondria y Estrés oxidativo en patología”.
Puesto administrativo:
Director del Programa de Bachillerato en Ciencias Universidad Andrés Bello. (2005-2009).
EXPERIENCIAS DOCENTES
– Profesor de Bioquímica, Facultad de Medicina, Pontificia Universidad Católica de Chile, 1993.
- Profesor de Farmacología de la Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, 1994.
- Tutor de Diseño de Drogas, Departamento de Farmacología Molecular, Albert Einstein College of Medicine, 1999.
- Profesor de Imagen de Resonancia Magnética Nuclear del Cerebro, Universidad de los Andes, noviembre de 2002.
- Profesor de Farmacología de la Facultad de Medicina de la Universidad de los Andes, 2003-2004
- Conferencias de Endocrinología de la Facultad de Medicina de la Universidad de Los Andes 2004
- Conferencias de Endocrinología, Departamento de Ciencias Biológicas de la Universidad Andrés Bello 2005
- Profesor de Farmacología para estudiantes de pregrado del Departamento de Bioquímica de Ciencias Biológicas de la Universidad Andrés Bello
- Profesor de Neurociencias a los estudiantes de pregrado del Departamento de Bioquímica de Ciencias Biológicas de la Universidad Andrés Bello
- Profesor de Farmacología de los estudiantes de medicina, Departamento de Ciencias Biológicas de la Universidad Andrés Bello.
- El profesor de fisiología celular a estudiantes de posgrado en el programa de doctorado Biociencias Moleculares.